Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses

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dc.contributor.authorGervassi, Anaen_ZA
dc.contributor.authorLejarcegui, Nicholasen_ZA
dc.contributor.authorDross, Sandraen_ZA
dc.contributor.authorJacobson, Amandaen_ZA
dc.contributor.authorItaya, Graceen_ZA
dc.contributor.authorKidzeru, Elvisen_ZA
dc.contributor.authorGantt, Sorenen_ZA
dc.contributor.authorJaspan, Heatheren_ZA
dc.contributor.authorHorton, Helenen_ZA
dc.date.accessioned2015-11-23T12:35:20Z
dc.date.available2015-11-23T12:35:20Z
dc.date.issued2014en_ZA
dc.description.abstractOver 4 million infants die each year from infections, many of which are vaccine-preventable. Young infants respond relatively poorly to many infections and vaccines, but the basis of reduced immunity in infants is ill defined. We sought to investigate whether myeloid-derived suppressor cells (MDSC) represent one potential impediment to protective immunity in early life, which may help inform strategies for effective vaccination prior to pathogen exposure. We enrolled healthy neonates and children in the first 2 years of life along with healthy adult controls to examine the frequency and function of MDSC, a cell population able to potently suppress T cell responses. We found that MDSC, which are rarely seen in healthy adults, are present in high numbers in neonates and their frequency rapidly decreases during the first months of life. We determined that these neonatal MDSC are of granulocytic origin (G-MDSC), and suppress both CD4+ and CD8+ T cell proliferative responses in a contact-dependent manner and gamma interferon production. Understanding the role G-MDSC play in infant immunity could improve vaccine responsiveness in newborns and reduce mortality due to early-life infections.en_ZA
dc.identifier.apacitationGervassi, A., Lejarcegui, N., Dross, S., Jacobson, A., Itaya, G., Kidzeru, E., ... Horton, H. (2014). Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses. <i>PLoS One</i>, http://hdl.handle.net/11427/15323en_ZA
dc.identifier.chicagocitationGervassi, Ana, Nicholas Lejarcegui, Sandra Dross, Amanda Jacobson, Grace Itaya, Elvis Kidzeru, Soren Gantt, Heather Jaspan, and Helen Horton "Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses." <i>PLoS One</i> (2014) http://hdl.handle.net/11427/15323en_ZA
dc.identifier.citationGervassi, A., Lejarcegui, N., Dross, S., Jacobson, A., Itaya, G., Kidzeru, E., ... & Horton, H. (2014). Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses. PloS one, 9(9), e107816. doi:10.1371/journal.pone.0107816en_ZA
dc.identifier.ris TY - Journal Article AU - Gervassi, Ana AU - Lejarcegui, Nicholas AU - Dross, Sandra AU - Jacobson, Amanda AU - Itaya, Grace AU - Kidzeru, Elvis AU - Gantt, Soren AU - Jaspan, Heather AU - Horton, Helen AB - Over 4 million infants die each year from infections, many of which are vaccine-preventable. Young infants respond relatively poorly to many infections and vaccines, but the basis of reduced immunity in infants is ill defined. We sought to investigate whether myeloid-derived suppressor cells (MDSC) represent one potential impediment to protective immunity in early life, which may help inform strategies for effective vaccination prior to pathogen exposure. We enrolled healthy neonates and children in the first 2 years of life along with healthy adult controls to examine the frequency and function of MDSC, a cell population able to potently suppress T cell responses. We found that MDSC, which are rarely seen in healthy adults, are present in high numbers in neonates and their frequency rapidly decreases during the first months of life. We determined that these neonatal MDSC are of granulocytic origin (G-MDSC), and suppress both CD4+ and CD8+ T cell proliferative responses in a contact-dependent manner and gamma interferon production. Understanding the role G-MDSC play in infant immunity could improve vaccine responsiveness in newborns and reduce mortality due to early-life infections. DA - 2014 DB - OpenUCT DO - 10.1371/journal.pone.0107816 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses TI - Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses UR - http://hdl.handle.net/11427/15323 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15323
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0107816
dc.identifier.vancouvercitationGervassi A, Lejarcegui N, Dross S, Jacobson A, Itaya G, Kidzeru E, et al. Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses. PLoS One. 2014; http://hdl.handle.net/11427/15323.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2014 Gervassi et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherT cellsen_ZA
dc.subject.otherAdultsen_ZA
dc.subject.otherInfantsen_ZA
dc.subject.otherNeutrophilsen_ZA
dc.subject.otherBlooden_ZA
dc.subject.otherImmune responseen_ZA
dc.subject.otherNeonatesen_ZA
dc.subject.otherVaccinesen_ZA
dc.titleMyeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responsesen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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