Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures

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dc.contributor.advisorLaubscher, Maritz
dc.contributor.advisorMaqungo Sithombo
dc.contributor.authorBotha, Peter
dc.date.accessioned2025-06-25T11:51:10Z
dc.date.available2025-06-25T11:51:10Z
dc.date.issued2025
dc.date.updated2025-06-25T11:47:27Z
dc.description.abstractBackground: Osteoporosis is a global health issue causing a deterioration in bone microarchitecture, compromising bone strength. In South Africa (SA), the prevalence of osteoporosis is a growing concern for both HIV-positive and HIVnegative individuals. The aim of this study was to assess the impact of HIV infection on bone mineral density (BMD) in HIV-positive individuals and compare this to the BMD in HIV-negative individuals with traumatic long-bone fractures. In addition, we compared the impact of demographics, nutritional (albumin), Vitamin D status and smoking between HIV-positive and negative individuals. Patients and Methods: We retrospectively reviewed data from a prospectively collected database within the HIV in Orthopaedic Skeletal Trauma (HOST) study conducted at tertiary care hospitals. This study included all individuals with a confirmed HIV positive or negative status who had their BMD measurement performed using a calcaneal quantitative ultrasound scan (cQUS) and excluded those individuals who had never had a cQUS performed. Results: Of 400 individuals recruited from the parent study, 172 (43%) had their BMD measured. 27(15.7%) were HIV-positive. Overall, the BMD and T-scores were similar in both the HIV-positive and HIV-negative participants with a median BMD of 0.49 g/cm2 (0.23 – 0.71) within the HIV positive group; 0.49 (0.3-0.71) within the HIV negative group and an overall T-score of -0.8, with no statistical significance found between the two groups (p>0.050). Age, smoking status, Vitamin D, Albumin and BMI had no effect on BMD (p> 0.050). Conclusion: We found a higher proportion of patients with osteoporosis within the HIV-positive cohort, although not statistically significant and no statistically significant difference in the median BMD between the HIV -positive and HIVnegative subgroups. Neither age, smoking, vitamin D, albumin nor BMI was associated with a lower BMD
dc.identifier.apacitationBotha, P. (2025). <i>Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures</i>. (). University of Cape town ,Faculty of Health Sciences ,Division of General Surgery. Retrieved from http://hdl.handle.net/11427/41486en_ZA
dc.identifier.chicagocitationBotha, Peter. <i>"Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures."</i> ., University of Cape town ,Faculty of Health Sciences ,Division of General Surgery, 2025. http://hdl.handle.net/11427/41486en_ZA
dc.identifier.citationBotha, P. 2025. Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures. . University of Cape town ,Faculty of Health Sciences ,Division of General Surgery. http://hdl.handle.net/11427/41486en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Botha, Peter AB - Background: Osteoporosis is a global health issue causing a deterioration in bone microarchitecture, compromising bone strength. In South Africa (SA), the prevalence of osteoporosis is a growing concern for both HIV-positive and HIVnegative individuals. The aim of this study was to assess the impact of HIV infection on bone mineral density (BMD) in HIV-positive individuals and compare this to the BMD in HIV-negative individuals with traumatic long-bone fractures. In addition, we compared the impact of demographics, nutritional (albumin), Vitamin D status and smoking between HIV-positive and negative individuals. Patients and Methods: We retrospectively reviewed data from a prospectively collected database within the HIV in Orthopaedic Skeletal Trauma (HOST) study conducted at tertiary care hospitals. This study included all individuals with a confirmed HIV positive or negative status who had their BMD measurement performed using a calcaneal quantitative ultrasound scan (cQUS) and excluded those individuals who had never had a cQUS performed. Results: Of 400 individuals recruited from the parent study, 172 (43%) had their BMD measured. 27(15.7%) were HIV-positive. Overall, the BMD and T-scores were similar in both the HIV-positive and HIV-negative participants with a median BMD of 0.49 g/cm2 (0.23 – 0.71) within the HIV positive group; 0.49 (0.3-0.71) within the HIV negative group and an overall T-score of -0.8, with no statistical significance found between the two groups (p>0.050). Age, smoking status, Vitamin D, Albumin and BMI had no effect on BMD (p> 0.050). Conclusion: We found a higher proportion of patients with osteoporosis within the HIV-positive cohort, although not statistically significant and no statistically significant difference in the median BMD between the HIV -positive and HIVnegative subgroups. Neither age, smoking, vitamin D, albumin nor BMI was associated with a lower BMD DA - 2025 DB - OpenUCT DP - University of Cape Town KW - General Surgery LK - https://open.uct.ac.za PB - University of Cape town PY - 2025 T1 - Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures TI - Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures UR - http://hdl.handle.net/11427/41486 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/41486
dc.identifier.vancouvercitationBotha P. Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures. []. University of Cape town ,Faculty of Health Sciences ,Division of General Surgery, 2025 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/41486en_ZA
dc.language.rfc3066Eng
dc.publisher.departmentDivision of General Surgery
dc.publisher.facultyFaculty of Health Sciences
dc.publisher.institutionUniversity of Cape town
dc.subjectGeneral Surgery
dc.titleBone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures
dc.typeThesis / Dissertation
dc.type.qualificationlevelMasters
dc.type.qualificationlevelMMed
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