The evolving management of Burkitt's lymphoma at Red CrossChildren's Hospital

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dc.contributor.authorDavidson, Alan
dc.contributor.authorDesai, Farieda
dc.contributor.authorHendricks, Marc
dc.contributor.authorHartley, Patricia
dc.contributor.authorMillar, Alastair
dc.contributor.authorNumanoglu, Alp
dc.contributor.authorRode, Heinz
dc.date.accessioned2017-05-16T12:12:02Z
dc.date.available2017-05-16T12:12:02Z
dc.date.issued2006
dc.date.updated2016-01-08T09:09:17Z
dc.description.abstractBackground. Treatment for Burkitt’s lymphoma at Red Cross Children’s Hospital has evolved from the use of aggressive surgery and less intensive chemotherapy to a conservative surgical approach with more intensive chemotherapy. Methods. The study was a retrospective folder review of patients diagnosed with Burkitt’s lymphoma at RCCH between 1984 and 2004. Results. Ninety-two children were treated for Burkitt’s lymphoma at RCCH between 1984 and 2004. There were 10 patients with group A or fully resected disease, 52 with group B or extensive localised disease, and 30 with dissemination to the bone marrow and/or central nervous system or group C disease. Protocol 1 (less intensive chemotherapy based on the COMP regimen) was used from 1984, with protocol 2 (more intensive chemotherapy based on the LMB regimen) introduced in 1988 for group C disease, 1991 for group B disease and 1996 for group A disease. Overall 5-year survival increased from 20% with protocol 1 to 66% with protocol 2 for group C disease, and from 76.5% with protocol 1 to 88.2% with protocol 2 for group B disease. There were more admissions for neutropenic fever in patients on protocol 2 and more episodes of mucositis, and these patients required more red cell and platelet transfusions. With a more conservative surgical approach, biopsy largely replaced attempts to partially resect the tumour at primary surgery, and there was a consequent decline in surgical complications. Conclusions. Intensive chemotherapy with protocol 2 has resulted in improved survival for group C and group B patients, but with more morbidity. Protocol 1, which is less intensive with less morbidity, remains a viable strategy for group A and group B disease in resource-poor settings.
dc.identifierhttp://dx.doi.org/10.7196/SAMJ.1293
dc.identifier.apacitationDavidson, A., Desai, F., Hendricks, M., Hartley, P., Millar, A., Numanoglu, A., & Rode, H. (2006). The evolving management of Burkitt's lymphoma at Red CrossChildren's Hospital. <i>South African Medical Journal</i>, http://hdl.handle.net/11427/24330en_ZA
dc.identifier.chicagocitationDavidson, Alan, Farieda Desai, Marc Hendricks, Patricia Hartley, Alastair Millar, Alp Numanoglu, and Heinz Rode "The evolving management of Burkitt's lymphoma at Red CrossChildren's Hospital." <i>South African Medical Journal</i> (2006) http://hdl.handle.net/11427/24330en_ZA
dc.identifier.citationDavidson, A., Desai, F., Hendricks, M., Hartley, P., Millar, A., Numanoglu, A., & Rode, H. (2008). The evolving management of Burkitt's lymphoma at Red Cross Children's Hospital. South African Medical Journal, 96(9), 950.
dc.identifier.ris TY - Journal Article AU - Davidson, Alan AU - Desai, Farieda AU - Hendricks, Marc AU - Hartley, Patricia AU - Millar, Alastair AU - Numanoglu, Alp AU - Rode, Heinz AB - Background. Treatment for Burkitt’s lymphoma at Red Cross Children’s Hospital has evolved from the use of aggressive surgery and less intensive chemotherapy to a conservative surgical approach with more intensive chemotherapy. Methods. The study was a retrospective folder review of patients diagnosed with Burkitt’s lymphoma at RCCH between 1984 and 2004. Results. Ninety-two children were treated for Burkitt’s lymphoma at RCCH between 1984 and 2004. There were 10 patients with group A or fully resected disease, 52 with group B or extensive localised disease, and 30 with dissemination to the bone marrow and/or central nervous system or group C disease. Protocol 1 (less intensive chemotherapy based on the COMP regimen) was used from 1984, with protocol 2 (more intensive chemotherapy based on the LMB regimen) introduced in 1988 for group C disease, 1991 for group B disease and 1996 for group A disease. Overall 5-year survival increased from 20% with protocol 1 to 66% with protocol 2 for group C disease, and from 76.5% with protocol 1 to 88.2% with protocol 2 for group B disease. There were more admissions for neutropenic fever in patients on protocol 2 and more episodes of mucositis, and these patients required more red cell and platelet transfusions. With a more conservative surgical approach, biopsy largely replaced attempts to partially resect the tumour at primary surgery, and there was a consequent decline in surgical complications. Conclusions. Intensive chemotherapy with protocol 2 has resulted in improved survival for group C and group B patients, but with more morbidity. Protocol 1, which is less intensive with less morbidity, remains a viable strategy for group A and group B disease in resource-poor settings. DA - 2006 DB - OpenUCT DP - University of Cape Town J1 - South African Medical Journal LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - The evolving management of Burkitt's lymphoma at Red CrossChildren's Hospital TI - The evolving management of Burkitt's lymphoma at Red CrossChildren's Hospital UR - http://hdl.handle.net/11427/24330 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/24330
dc.identifier.vancouvercitationDavidson A, Desai F, Hendricks M, Hartley P, Millar A, Numanoglu A, et al. The evolving management of Burkitt's lymphoma at Red CrossChildren's Hospital. South African Medical Journal. 2006; http://hdl.handle.net/11427/24330.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Haematologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceSouth African Medical Journal
dc.source.urihttp://www.samj.org.za/index.php/samj
dc.titleThe evolving management of Burkitt's lymphoma at Red CrossChildren's Hospital
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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