Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals

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dc.contributor.authorLambert, Estelle V
dc.contributor.authorGoedecke, Julia H
dc.contributor.authorBluett, Kerry
dc.contributor.authorHeggie, Kerry
dc.contributor.authorClaassen, Amanda
dc.contributor.authorRae, Dale E
dc.contributor.authorWest, Sacha
dc.contributor.authorDugas, Jonathan
dc.contributor.authorDugas, Lara
dc.contributor.authorMeltzer, Shelly
dc.contributor.authorCharlton, Karen
dc.contributor.authorMohede, Inge
dc.date.accessioned2021-10-08T07:20:42Z
dc.date.available2021-10-08T07:20:42Z
dc.date.issued2007
dc.description.abstractThe aim of this study was to measure the effects of 12 weeks of conjugated linoleic acid (CLA) supplementation on body composition, RER, RMR, blood lipid profiles, insulin sensitivity and appetite in exercising, normal-weight persons. In this double-blind, randomised, controlled trial, sixty-two non-obese subjects (twenty-five men, thirty-seven women) received either 3.9 g/d CLA or 3.9 g high-oleic acid sunflower oil for 12 weeks. Prior to and after 12 weeks of supplementation, oral glucose tolerance, blood lipid concentrations, body composition (dual-energy X-ray absorptiometry and computerised tomography scans), RMR, resting and exercising RER and appetite were measured. There were no significant effects of CLA on body composition or distribution, RMR, RER or appetite. During the oral glucose tolerance tests, mean plasma insulin concentrations (0, 30, 120 min) were significantly lower (P= 0.04) in women who supplemented with CLA (24.3 (SD 9.7) to 20.4 (SD 8.5) microU/ml) compared to high-oleic acid sunflower oil control (23.7 (SD 9.8) to 26.0 (SD 8.8) microU/ml). Serum NEFA levels in response to oral glucose were attenuated in both men and women in the CLA (P=0.001) compared to control group. However, serum total cholesterol and LDL-cholesterol concentrations decreased in both groups and HDL-cholesterol concentrations decreased in women over 12 weeks (P=0.001, P=0.02, P=0.02, respectively). In conclusion, mixed-isomer CLA supplementation had a favourable effect on serum insulin and NEFA response to oral glucose in non-obese, regularly exercising women, but there were no CLA-specific effects on body composition, energy expenditure or appetite.
dc.identifier.apacitationLambert, E. V., Goedecke, J. H., Bluett, K., Heggie, K., Claassen, A., Rae, D. E., ... Mohede, I. (2007). Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals. <i>The British Journal of Nutrition</i>, 97(5), 1001 - 177. http://hdl.handle.net/11427/34985en_ZA
dc.identifier.chicagocitationLambert, Estelle V, Julia H Goedecke, Kerry Bluett, Kerry Heggie, Amanda Claassen, Dale E Rae, Sacha West, et al "Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals." <i>The British Journal of Nutrition</i> 97, 5. (2007): 1001 - 177. http://hdl.handle.net/11427/34985en_ZA
dc.identifier.citationLambert, E.V., Goedecke, J.H., Bluett, K., Heggie, K., Claassen, A., Rae, D.E., West, S. & Dugas, J. et al. 2007. Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals. <i>The British Journal of Nutrition.</i> 97(5):1001 - 177. http://hdl.handle.net/11427/34985en_ZA
dc.identifier.issn0007-1145
dc.identifier.issn1475-2662
dc.identifier.ris TY - Journal Article AU - Lambert, Estelle V AU - Goedecke, Julia H AU - Bluett, Kerry AU - Heggie, Kerry AU - Claassen, Amanda AU - Rae, Dale E AU - West, Sacha AU - Dugas, Jonathan AU - Dugas, Lara AU - Meltzer, Shelly AU - Charlton, Karen AU - Mohede, Inge AB - The aim of this study was to measure the effects of 12 weeks of conjugated linoleic acid (CLA) supplementation on body composition, RER, RMR, blood lipid profiles, insulin sensitivity and appetite in exercising, normal-weight persons. In this double-blind, randomised, controlled trial, sixty-two non-obese subjects (twenty-five men, thirty-seven women) received either 3.9 g/d CLA or 3.9 g high-oleic acid sunflower oil for 12 weeks. Prior to and after 12 weeks of supplementation, oral glucose tolerance, blood lipid concentrations, body composition (dual-energy X-ray absorptiometry and computerised tomography scans), RMR, resting and exercising RER and appetite were measured. There were no significant effects of CLA on body composition or distribution, RMR, RER or appetite. During the oral glucose tolerance tests, mean plasma insulin concentrations (0, 30, 120 min) were significantly lower (P= 0.04) in women who supplemented with CLA (24.3 (SD 9.7) to 20.4 (SD 8.5) microU/ml) compared to high-oleic acid sunflower oil control (23.7 (SD 9.8) to 26.0 (SD 8.8) microU/ml). Serum NEFA levels in response to oral glucose were attenuated in both men and women in the CLA (P=0.001) compared to control group. However, serum total cholesterol and LDL-cholesterol concentrations decreased in both groups and HDL-cholesterol concentrations decreased in women over 12 weeks (P=0.001, P=0.02, P=0.02, respectively). In conclusion, mixed-isomer CLA supplementation had a favourable effect on serum insulin and NEFA response to oral glucose in non-obese, regularly exercising women, but there were no CLA-specific effects on body composition, energy expenditure or appetite. DA - 2007 DB - OpenUCT DP - University of Cape Town IS - 5 J1 - The British Journal of Nutrition LK - https://open.uct.ac.za PY - 2007 SM - 0007-1145 SM - 1475-2662 T1 - Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals TI - Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals UR - http://hdl.handle.net/11427/34985 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34985
dc.identifier.vancouvercitationLambert EV, Goedecke JH, Bluett K, Heggie K, Claassen A, Rae DE, et al. Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals. The British Journal of Nutrition. 2007;97(5):1001 - 177. http://hdl.handle.net/11427/34985.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Human Biology
dc.publisher.facultyFaculty of Health Sciences
dc.sourceThe British Journal of Nutrition
dc.source.journalissue5
dc.source.journalvolume97
dc.source.pagination1001 - 177
dc.source.urihttps://dx.doi.org/10.1017/S0007114507172822
dc.subject.otherExercise metabolism: Insulin sensitivity: Body fat distribution: CLA isomers
dc.subject.otherMammalia
dc.subject.otherIsomer
dc.subject.otherDistribution
dc.subject.otherFat
dc.subject.otherSensitivity
dc.subject.otherInsulin
dc.subject.otherHuman
dc.subject.otherPhysical exercise
dc.subject.otherBody composition
dc.subject.otherAppetite
dc.subject.otherLipids
dc.subject.otherBlood
dc.subject.otherTolerance
dc.subject.otherGlucose
dc.subject.otherEnergy metabolism
dc.subject.otherSunflower oil
dc.subject.otherMonounsaturated fatty acid
dc.subject.otherOleic acid
dc.subject.otherComparative study
dc.subject.otherConjugated linoleic acid
dc.subject.otherVertebrata
dc.subject.otherPancreatic hormone
dc.subject.otherIsomère
dc.subject.otherMatière grasse
dc.subject.otherSensibilité
dc.titleConjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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