Surfactant Protein-D is essential for immunity to Helminth Infection

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dc.contributor.authorThawer, Sumaiyyaen_ZA
dc.contributor.authorAuret, Jenniferen_ZA
dc.contributor.authorSchnoeller, Corinnaen_ZA
dc.contributor.authorChetty, Alishaen_ZA
dc.contributor.authorSmith, Katherineen_ZA
dc.contributor.authorDarby, Matthewen_ZA
dc.contributor.authorRoberts, Lukeen_ZA
dc.contributor.authorMackay, Rosie-Marieen_ZA
dc.contributor.authorWhitwell, Harry Jen_ZA
dc.contributor.authorTimms, John Fen_ZA
dc.contributor.authorMadsen, Jensen_ZA
dc.contributor.authorSelkirk, Murray Een_ZA
dc.contributor.authorBrombacher, Franken_ZA
dc.contributor.authorClark, Howard Williamen_ZA
dc.contributor.authorHorsnell, William G Cen_ZA
dc.date.accessioned2016-03-08T10:54:20Z
dc.date.available2016-03-08T10:54:20Z
dc.date.issued2016en_ZA
dc.description.abstractAuthor Summary Infections by parasitic worms are very common, and controlling them is a major medical and veterinary challenge. Very few drugs exist to treat them, and the parasites can develop resistance to these. In order to find new ways to control worm infections, understanding how our immune system responds to them is essential. Many important parasitic worm infections move through the host lung. In this study we show that a major secreted protein in the lung, Surfactant Protein D (SP-D), is essential for immunity to a parasitic worm infection. We found that this protein binds to worm larvae in the lung to help the immune system kill them. Infecting mice that do not express SP-D with worms demonstrates SP-D is important in this immune response. These mice are unable to launch an effective anti-worm immune response and have many more worms in their intestine compared to mice that do express SP-D. We also show that if we increase SP-D levels in the lung the mouse has better immunity to worms. Together this shows for the first time that SP-D is very important for immunity to worm infections.en_ZA
dc.identifier.apacitationThawer, S., Auret, J., Schnoeller, C., Chetty, A., Smith, K., Darby, M., ... Horsnell, W. G. C. (2016). Surfactant Protein-D is essential for immunity to Helminth Infection. <i>PLoS One</i>, http://hdl.handle.net/11427/17572en_ZA
dc.identifier.chicagocitationThawer, Sumaiyya, Jennifer Auret, Corinna Schnoeller, Alisha Chetty, Katherine Smith, Matthew Darby, Luke Roberts, et al "Surfactant Protein-D is essential for immunity to Helminth Infection." <i>PLoS One</i> (2016) http://hdl.handle.net/11427/17572en_ZA
dc.identifier.citationThawer, S., Auret, J., Schnoeller, C., Chetty, A., Smith, K., Darby, M., ... & Madsen, J. (2016). Surfactant Protein-D is essential for immunity to Helminth Infection. PLoS Pathog, 12(2), e1005461. doi:10.1371/journal.ppat.1005461en_ZA
dc.identifier.ris TY - Journal Article AU - Thawer, Sumaiyya AU - Auret, Jennifer AU - Schnoeller, Corinna AU - Chetty, Alisha AU - Smith, Katherine AU - Darby, Matthew AU - Roberts, Luke AU - Mackay, Rosie-Marie AU - Whitwell, Harry J AU - Timms, John F AU - Madsen, Jens AU - Selkirk, Murray E AU - Brombacher, Frank AU - Clark, Howard William AU - Horsnell, William G C AB - Author Summary Infections by parasitic worms are very common, and controlling them is a major medical and veterinary challenge. Very few drugs exist to treat them, and the parasites can develop resistance to these. In order to find new ways to control worm infections, understanding how our immune system responds to them is essential. Many important parasitic worm infections move through the host lung. In this study we show that a major secreted protein in the lung, Surfactant Protein D (SP-D), is essential for immunity to a parasitic worm infection. We found that this protein binds to worm larvae in the lung to help the immune system kill them. Infecting mice that do not express SP-D with worms demonstrates SP-D is important in this immune response. These mice are unable to launch an effective anti-worm immune response and have many more worms in their intestine compared to mice that do express SP-D. We also show that if we increase SP-D levels in the lung the mouse has better immunity to worms. Together this shows for the first time that SP-D is very important for immunity to worm infections. DA - 2016 DB - OpenUCT DO - 10.1371/journal.ppat.1005461 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Surfactant Protein-D is essential for immunity to Helminth Infection TI - Surfactant Protein-D is essential for immunity to Helminth Infection UR - http://hdl.handle.net/11427/17572 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1371/journal.ppat.1005461en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/17572
dc.identifier.vancouvercitationThawer S, Auret J, Schnoeller C, Chetty A, Smith K, Darby M, et al. Surfactant Protein-D is essential for immunity to Helminth Infection. PLoS One. 2016; http://hdl.handle.net/11427/17572.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2016 Thawer et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plospathogensen_ZA
dc.subject.otherAlveolar macrophagesen_ZA
dc.subject.otherHelminth infectionsen_ZA
dc.subject.otherHost-pathogen interactionsen_ZA
dc.subject.otherInfectious disease immunologyen_ZA
dc.subject.otherImmunityen_ZA
dc.subject.otherCell-mediated immunityen_ZA
dc.subject.otherEnzyme-linked immunoassaysen_ZA
dc.subject.otherImmune responseen_ZA
dc.titleSurfactant Protein-D is essential for immunity to Helminth Infectionen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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