Chronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertension

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dc.contributor.authorDiaba-Nuhoho, Patrick
dc.contributor.authorCour, Martin
dc.contributor.authorHadebe, Nkanyiso
dc.contributor.authorMarais, David
dc.contributor.authorLecour, Sandrine
dc.contributor.authorBlackhurst, Dee
dc.date.accessioned2021-10-06T09:50:54Z
dc.date.available2021-10-06T09:50:54Z
dc.date.issued2021-08-23
dc.date.updated2021-08-29T03:10:38Z
dc.description.abstractObjectives In pulmonary arterial hypertension (PAH), right ventricular (RV) dysfunction develops via mechanisms involving oxidative stress. Moderate and chronic red wine (RW) consumption reduces oxidative stress and confers cardioprotection but its effect on PAH is unknown. We evaluated whether moderate and chronic consumption of reduced-alcohol RW (RARW) confers cardioprotection in a monocrotaline (MCT)-induced PAH rat model. Results Rats were randomly grouped: control; MCT; RARW; MCT + RARW. Wine was diluted to mimic moderate intake for humans, and consumed from 7 days before, until 28 days after MCT-injection. Echocardiography measured pulmonary artery acceleration time (PAAT) and RV thickness. Conjugated dienes (CD), and thiobarbituric acid reactive substances (TBARS) concentrations were assessed. MCT induced RV thickness and decreased PAAT compared to controls [1.22 ± 0.09 mm vs 0.46 ± 0.02 mm and 14 ± 1 vs 23 ± 2 m/s, respectively (p < 0.001)]. Chronic RARW consumption limited MCT-induced RV hypertrophy and increased PAAT. CD and TBARS increased in MCT-treated animals compared to controls (672 ± 43 nmol/L vs 453 ± 35 nmol/L; p < 0.01 and 13 ± 2 µmol/L vs 4 ± 0.3 µmol/L; p < 0.01). RARW reduced MCT-induced CD (472 ± 27 nmol/L vs 672 ± 43 nmol/L; p < 0.01). Conclusion Chronic and moderate intake of RARW ameliorates MCT-induced PAH in rats, which may be partly attributable to reduction of lipid peroxidation.en_US
dc.identifier.apacitationDiaba-Nuhoho, P., Cour, M., Hadebe, N., Marais, D., Lecour, S., & Blackhurst, D. (2021). Chronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertension. <i>BMC Research Notes</i>, 14(Article number: 324), http://hdl.handle.net/11427/34096en_ZA
dc.identifier.chicagocitationDiaba-Nuhoho, Patrick, Martin Cour, Nkanyiso Hadebe, David Marais, Sandrine Lecour, and Dee Blackhurst "Chronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertension." <i>BMC Research Notes</i> 14, Article number: 324. (2021) http://hdl.handle.net/11427/34096en_ZA
dc.identifier.citationDiaba-Nuhoho, P., Cour, M., Hadebe, N., Marais, D., Lecour, S. & Blackhurst, D. 2021. Chronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertension. <i>BMC Research Notes.</i> 14(Article number: 324) http://hdl.handle.net/11427/34096en_ZA
dc.identifier.ris TY - Journal Article AU - Diaba-Nuhoho, Patrick AU - Cour, Martin AU - Hadebe, Nkanyiso AU - Marais, David AU - Lecour, Sandrine AU - Blackhurst, Dee AB - Objectives In pulmonary arterial hypertension (PAH), right ventricular (RV) dysfunction develops via mechanisms involving oxidative stress. Moderate and chronic red wine (RW) consumption reduces oxidative stress and confers cardioprotection but its effect on PAH is unknown. We evaluated whether moderate and chronic consumption of reduced-alcohol RW (RARW) confers cardioprotection in a monocrotaline (MCT)-induced PAH rat model. Results Rats were randomly grouped: control; MCT; RARW; MCT + RARW. Wine was diluted to mimic moderate intake for humans, and consumed from 7 days before, until 28 days after MCT-injection. Echocardiography measured pulmonary artery acceleration time (PAAT) and RV thickness. Conjugated dienes (CD), and thiobarbituric acid reactive substances (TBARS) concentrations were assessed. MCT induced RV thickness and decreased PAAT compared to controls [1.22 ± 0.09 mm vs 0.46 ± 0.02 mm and 14 ± 1 vs 23 ± 2 m/s, respectively (p < 0.001)]. Chronic RARW consumption limited MCT-induced RV hypertrophy and increased PAAT. CD and TBARS increased in MCT-treated animals compared to controls (672 ± 43 nmol/L vs 453 ± 35 nmol/L; p < 0.01 and 13 ± 2 µmol/L vs 4 ± 0.3 µmol/L; p < 0.01). RARW reduced MCT-induced CD (472 ± 27 nmol/L vs 672 ± 43 nmol/L; p < 0.01). Conclusion Chronic and moderate intake of RARW ameliorates MCT-induced PAH in rats, which may be partly attributable to reduction of lipid peroxidation. DA - 2021-08-23 DB - OpenUCT DP - University of Cape Town IS - Article number: 324 J1 - BMC Research Notes KW - Antioxidants KW - Monocrotaline KW - Oxidative stress KW - Pulmonary arterial hypertension KW - Red wine LK - https://open.uct.ac.za PY - 2021 T1 - Chronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertension TI - Chronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertension UR - http://hdl.handle.net/11427/34096 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s13104-021-05738-x
dc.identifier.urihttp://hdl.handle.net/11427/34096
dc.identifier.vancouvercitationDiaba-Nuhoho P, Cour M, Hadebe N, Marais D, Lecour S, Blackhurst D. Chronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertension. BMC Research Notes. 2021;14(Article number: 324) http://hdl.handle.net/11427/34096.en_ZA
dc.language.isoenen_US
dc.language.rfc3066en
dc.publisher.departmentDepartment of Pathologyen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceBMC Research Notesen_US
dc.source.journalissueArticle number: 324en_US
dc.source.journalvolume14en_US
dc.source.urihttps://bmcresnotes.biomedcentral.com/
dc.subjectAntioxidantsen_US
dc.subjectMonocrotalineen_US
dc.subjectOxidative stressen_US
dc.subjectPulmonary arterial hypertensionen_US
dc.subjectRed wineen_US
dc.titleChronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertensionen_US
dc.typeJournal Articleen_US
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