Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study

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dc.contributor.advisorHill, Laurenen_ZA
dc.contributor.advisorDavids, Lesteren_ZA
dc.contributor.authorKatundu, Kondwanien_ZA
dc.date.accessioned2015-07-02T08:37:25Z
dc.date.available2015-07-02T08:37:25Z
dc.date.issued2014en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractSeptic shock is associated with oxidative stress, reduced levels of plasma vitamin C and stress hyperglycaemia – all factors that may influence endothelial, and therefore, organ function. Vitamin C is an important antioxidant in human plasma; and it has been implicated in maintaining normal endothelial function during oxidative stress. The vitamin C status of critically ill patients in South African ICUs has not been well investigated; neither has the relationship between vitamin C status, oxidative stress, hyperglycaemia and endothelial function been studied in this patient group. In a prospective, cross-sectional study investigating these factors in critically ill patients with septic shock on inotropic support, serial blood samples from 25 patients were taken at days zero and one, following inotrope initiation, and on day seven after inotrope cessation. These samples were analysed for plasma vitamin C, thiobarbituric acid-reactive substances (TBARS) - as a biomarker of oxidative stress - and soluble vascular cell adhesion molecule-1 (sVCAM-1), and E-selectin, as markers of endothelial dysfunction. The plasma glucose to vitamin C ratios were also calculated. Daily clinical measures in the patients included Sequential Organ Failure Assessment (SOFA) score, mean arterial blood pressure, blood glucose, fluid balance and inotropic support. The clinical outcomes were recorded.en_ZA
dc.identifier.apacitationKatundu, K. (2014). <i>Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/13286en_ZA
dc.identifier.chicagocitationKatundu, Kondwani. <i>"Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2014. http://hdl.handle.net/11427/13286en_ZA
dc.identifier.citationKatundu, K. 2014. Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Katundu, Kondwani AB - Septic shock is associated with oxidative stress, reduced levels of plasma vitamin C and stress hyperglycaemia – all factors that may influence endothelial, and therefore, organ function. Vitamin C is an important antioxidant in human plasma; and it has been implicated in maintaining normal endothelial function during oxidative stress. The vitamin C status of critically ill patients in South African ICUs has not been well investigated; neither has the relationship between vitamin C status, oxidative stress, hyperglycaemia and endothelial function been studied in this patient group. In a prospective, cross-sectional study investigating these factors in critically ill patients with septic shock on inotropic support, serial blood samples from 25 patients were taken at days zero and one, following inotrope initiation, and on day seven after inotrope cessation. These samples were analysed for plasma vitamin C, thiobarbituric acid-reactive substances (TBARS) - as a biomarker of oxidative stress - and soluble vascular cell adhesion molecule-1 (sVCAM-1), and E-selectin, as markers of endothelial dysfunction. The plasma glucose to vitamin C ratios were also calculated. Daily clinical measures in the patients included Sequential Organ Failure Assessment (SOFA) score, mean arterial blood pressure, blood glucose, fluid balance and inotropic support. The clinical outcomes were recorded. DA - 2014 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study TI - Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study UR - http://hdl.handle.net/11427/13286 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/13286
dc.identifier.vancouvercitationKatundu K. Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2014 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/13286en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherNutritionen_ZA
dc.titleVitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational studyen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMSc (Med)en_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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