Creating an African HIV clinical research and prevention trials network: HIV prevalence, incidence and transmission

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dc.contributor.authorKamali, Anatolien_ZA
dc.contributor.authorPrice, Matt Aen_ZA
dc.contributor.authorLakhi, Shabiren_ZA
dc.contributor.authorKarita, Etienneen_ZA
dc.contributor.authorInambao, Mubianaen_ZA
dc.contributor.authorSanders, Eduard Jen_ZA
dc.contributor.authorAnzala, Omuen_ZA
dc.contributor.authorLatka, Mary Hen_ZA
dc.contributor.authorBekker, Linda-Gailen_ZA
dc.contributor.authorKaleebu, Pontianoen_ZA
dc.date.accessioned2015-11-23T12:25:35Z
dc.date.available2015-11-23T12:25:35Z
dc.date.issued2015en_ZA
dc.description.abstractHIV epidemiology informs prevention trial design and program planning. Nine clinical research centers (CRC) in sub-Saharan Africa conducted HIV observational epidemiology studies in populations at risk for HIV infection as part of an HIV prevention and vaccine trial network. Annual HIV incidence ranged from below 2% to above 10% and varied by CRC and risk group, with rates above 5% observed in Zambian men in an HIV-discordant relationship, Ugandan men from Lake Victoria fishing communities, men who have sex with men, and several cohorts of women. HIV incidence tended to fall after the first three months in the study and over calendar time. Among suspected transmission pairs, 28% of HIV infections were not from the reported partner. Volunteers with high incidence were successfully identified and enrolled into large scale cohort studies. Over a quarter of new cases in couples acquired infection from persons other than the suspected transmitting partner.en_ZA
dc.identifier.apacitationKamali, A., Price, M. A., Lakhi, S., Karita, E., Inambao, M., Sanders, E. J., ... Kaleebu, P. (2015). Creating an African HIV clinical research and prevention trials network: HIV prevalence, incidence and transmission. <i>PLoS One</i>, http://hdl.handle.net/11427/15271en_ZA
dc.identifier.chicagocitationKamali, Anatoli, Matt A Price, Shabir Lakhi, Etienne Karita, Mubiana Inambao, Eduard J Sanders, Omu Anzala, Mary H Latka, Linda-Gail Bekker, and Pontiano Kaleebu "Creating an African HIV clinical research and prevention trials network: HIV prevalence, incidence and transmission." <i>PLoS One</i> (2015) http://hdl.handle.net/11427/15271en_ZA
dc.identifier.citationKamali, A., Price, M. A., Lakhi, S., Karita, E., Inambao, M., Sanders, E. J., ... & Partnership, T. I. A. H. P. (2015). Creating an African HIV clinical research and prevention trials network: HIV prevalence, incidence and transmission. PloS one, 10(1). doi:10.1371/journal.pone.0116100en_ZA
dc.identifier.ris TY - Journal Article AU - Kamali, Anatoli AU - Price, Matt A AU - Lakhi, Shabir AU - Karita, Etienne AU - Inambao, Mubiana AU - Sanders, Eduard J AU - Anzala, Omu AU - Latka, Mary H AU - Bekker, Linda-Gail AU - Kaleebu, Pontiano AB - HIV epidemiology informs prevention trial design and program planning. Nine clinical research centers (CRC) in sub-Saharan Africa conducted HIV observational epidemiology studies in populations at risk for HIV infection as part of an HIV prevention and vaccine trial network. Annual HIV incidence ranged from below 2% to above 10% and varied by CRC and risk group, with rates above 5% observed in Zambian men in an HIV-discordant relationship, Ugandan men from Lake Victoria fishing communities, men who have sex with men, and several cohorts of women. HIV incidence tended to fall after the first three months in the study and over calendar time. Among suspected transmission pairs, 28% of HIV infections were not from the reported partner. Volunteers with high incidence were successfully identified and enrolled into large scale cohort studies. Over a quarter of new cases in couples acquired infection from persons other than the suspected transmitting partner. DA - 2015 DB - OpenUCT DO - 10.1371/journal.pone.0116100 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Creating an African HIV clinical research and prevention trials network: HIV prevalence, incidence and transmission TI - Creating an African HIV clinical research and prevention trials network: HIV prevalence, incidence and transmission UR - http://hdl.handle.net/11427/15271 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15271
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0116100
dc.identifier.vancouvercitationKamali A, Price MA, Lakhi S, Karita E, Inambao M, Sanders EJ, et al. Creating an African HIV clinical research and prevention trials network: HIV prevalence, incidence and transmission. PLoS One. 2015; http://hdl.handle.net/11427/15271.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDesmond Tutu HIV Centreen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2015 Kamali et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherHIVen_ZA
dc.subject.otherHIV epidemiologyen_ZA
dc.subject.otherHIV infectionsen_ZA
dc.subject.otherHIV preventionen_ZA
dc.subject.otherUgandaen_ZA
dc.subject.otherKenyaen_ZA
dc.subject.otherMen who have sex with menen_ZA
dc.subject.otherHealth services researchen_ZA
dc.titleCreating an African HIV clinical research and prevention trials network: HIV prevalence, incidence and transmissionen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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