Neuroimaging genomics in psychiatry—a translational approach

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dc.contributor.authorMufford, Mary S
dc.contributor.authorStein, Dan J
dc.contributor.authorDalvie, Shareefa
dc.contributor.authorGroenewold, Nynke A
dc.contributor.authorThompson, Paul M
dc.contributor.authorJahanshad, Neda
dc.date.accessioned2021-10-08T07:04:06Z
dc.date.available2021-10-08T07:04:06Z
dc.date.issued2017
dc.description.abstractNeuroimaging genomics is a relatively new field focused on integrating genomic and imaging data in order to investigate the mechanisms underlying brain phenotypes and neuropsychiatric disorders. While early work in neuroimaging genomics focused on mapping the associations of candidate gene variants with neuroimaging measures in small cohorts, the lack of reproducible results inspired better-powered and unbiased large-scale approaches. Notably, genome-wide association studies (GWAS) of brain imaging in thousands of individuals around the world have led to a range of promising findings. Extensions of such approaches are now addressing epigenetics, gene-gene epistasis, and gene-environment interactions, not only in brain structure, but also in brain function. Complementary developments in systems biology might facilitate the translation of findings from basic neuroscience and neuroimaging genomics to clinical practice. Here, we review recent approaches in neuroimaging genomics-we highlight the latest discoveries, discuss advantages and limitations of current approaches, and consider directions by which the field can move forward to shed light on brain disorders.
dc.identifier.apacitationMufford, M. S., Stein, D. J., Dalvie, S., Groenewold, N. A., Thompson, P. M., & Jahanshad, N. (2017). Neuroimaging genomics in psychiatry—a translational approach. <i>Genome Medicine</i>, 9(1), 174 - 177. http://hdl.handle.net/11427/34428en_ZA
dc.identifier.chicagocitationMufford, Mary S, Dan J Stein, Shareefa Dalvie, Nynke A Groenewold, Paul M Thompson, and Neda Jahanshad "Neuroimaging genomics in psychiatry—a translational approach." <i>Genome Medicine</i> 9, 1. (2017): 174 - 177. http://hdl.handle.net/11427/34428en_ZA
dc.identifier.citationMufford, M.S., Stein, D.J., Dalvie, S., Groenewold, N.A., Thompson, P.M. & Jahanshad, N. 2017. Neuroimaging genomics in psychiatry—a translational approach. <i>Genome Medicine.</i> 9(1):174 - 177. http://hdl.handle.net/11427/34428en_ZA
dc.identifier.issn1756-994X
dc.identifier.ris TY - Journal Article AU - Mufford, Mary S AU - Stein, Dan J AU - Dalvie, Shareefa AU - Groenewold, Nynke A AU - Thompson, Paul M AU - Jahanshad, Neda AB - Neuroimaging genomics is a relatively new field focused on integrating genomic and imaging data in order to investigate the mechanisms underlying brain phenotypes and neuropsychiatric disorders. While early work in neuroimaging genomics focused on mapping the associations of candidate gene variants with neuroimaging measures in small cohorts, the lack of reproducible results inspired better-powered and unbiased large-scale approaches. Notably, genome-wide association studies (GWAS) of brain imaging in thousands of individuals around the world have led to a range of promising findings. Extensions of such approaches are now addressing epigenetics, gene-gene epistasis, and gene-environment interactions, not only in brain structure, but also in brain function. Complementary developments in systems biology might facilitate the translation of findings from basic neuroscience and neuroimaging genomics to clinical practice. Here, we review recent approaches in neuroimaging genomics-we highlight the latest discoveries, discuss advantages and limitations of current approaches, and consider directions by which the field can move forward to shed light on brain disorders. DA - 2017 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Genome Medicine LK - https://open.uct.ac.za PY - 2017 SM - 1756-994X T1 - Neuroimaging genomics in psychiatry—a translational approach TI - Neuroimaging genomics in psychiatry—a translational approach UR - http://hdl.handle.net/11427/34428 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34428
dc.identifier.vancouvercitationMufford MS, Stein DJ, Dalvie S, Groenewold NA, Thompson PM, Jahanshad N. Neuroimaging genomics in psychiatry—a translational approach. Genome Medicine. 2017;9(1):174 - 177. http://hdl.handle.net/11427/34428.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Pathology
dc.publisher.facultyFaculty of Health Sciences
dc.sourceGenome Medicine
dc.source.journalissue1
dc.source.journalvolume9
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1186/s13073-017-0496-z
dc.subject.otherBurns
dc.subject.otherDisaster Planning
dc.subject.otherHumans
dc.subject.otherMass Casualty Incidents
dc.subject.otherNational Health Programs
dc.subject.otherPractice Guidelines as Topic
dc.subject.otherSocieties, Medical
dc.subject.otherSouth Africa
dc.titleNeuroimaging genomics in psychiatry—a translational approach
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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