Aminoglycoside-induced hearing loss: South Africans at risk

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dc.contributor.authorBardien, Soraya
dc.contributor.authorde Jong, Greetje
dc.contributor.authorSchaaf, H Simon
dc.contributor.authorHarris, Tashneem
dc.contributor.authorFagan, Johan
dc.contributor.authorPetersen, Lucretia
dc.date.accessioned2017-05-02T09:21:15Z
dc.date.available2017-05-02T09:21:15Z
dc.date.issued2009
dc.date.updated2016-01-07T10:52:43Z
dc.description.abstractSouth Africa is currently experiencing a TB epidemic with an estimated incidence of 940/100 000 population/year, and the country has been ranked 4th among the 22 high-burden TB countries worldwide by the World Health Organization (WHO). A potentially devastating threat to TB control is the emergence of multidrug-resistant TB (MDR-TB) and, more recently, extensively drug-resistant TB (XDR-TB), mainly as a result of poor drug adherence by TB patients and incorrect management or treatment regimens by health providers; however, direct transmission of drug-resistant strains also plays an important role. The MDR/XDR-TB strains necessitate prolonged chemotherapy for up to 2 years or more, and the use of more toxic second-line drugs including the aminoglycoside (streptomycin, kanamycin and amikacin) and polypeptide (capreomycin) antibiotics. In South Africa, in accordance with WHO guidelines, streptomycin is used for retreatment of TB while kanamycin, amikacin and capreomycin are used to treat MDR/XDR-TB.
dc.identifierhttp://dx.doi.org/10.7196/SAMJ.3365
dc.identifier.apacitationBardien, S., de Jong, G., Schaaf, H. S., Harris, T., Fagan, J., & Petersen, L. (2009). Aminoglycoside-induced hearing loss: South Africans at risk. <i>South African Medical Journal</i>, http://hdl.handle.net/11427/24229en_ZA
dc.identifier.chicagocitationBardien, Soraya, Greetje de Jong, H Simon Schaaf, Tashneem Harris, Johan Fagan, and Lucretia Petersen "Aminoglycoside-induced hearing loss: South Africans at risk." <i>South African Medical Journal</i> (2009) http://hdl.handle.net/11427/24229en_ZA
dc.identifier.citationBardien, S., Schaaf, H., Harris, T., Petersen, L., de Jong, G., & Fagan, J. (2009). Aminoglycoside-induced hearing loss: South Africans at risk. South African Medical Journal, 99(6), 440.
dc.identifier.ris TY - Journal Article AU - Bardien, Soraya AU - de Jong, Greetje AU - Schaaf, H Simon AU - Harris, Tashneem AU - Fagan, Johan AU - Petersen, Lucretia AB - South Africa is currently experiencing a TB epidemic with an estimated incidence of 940/100 000 population/year, and the country has been ranked 4th among the 22 high-burden TB countries worldwide by the World Health Organization (WHO). A potentially devastating threat to TB control is the emergence of multidrug-resistant TB (MDR-TB) and, more recently, extensively drug-resistant TB (XDR-TB), mainly as a result of poor drug adherence by TB patients and incorrect management or treatment regimens by health providers; however, direct transmission of drug-resistant strains also plays an important role. The MDR/XDR-TB strains necessitate prolonged chemotherapy for up to 2 years or more, and the use of more toxic second-line drugs including the aminoglycoside (streptomycin, kanamycin and amikacin) and polypeptide (capreomycin) antibiotics. In South Africa, in accordance with WHO guidelines, streptomycin is used for retreatment of TB while kanamycin, amikacin and capreomycin are used to treat MDR/XDR-TB. DA - 2009 DB - OpenUCT DP - University of Cape Town J1 - South African Medical Journal LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Aminoglycoside-induced hearing loss: South Africans at risk TI - Aminoglycoside-induced hearing loss: South Africans at risk UR - http://hdl.handle.net/11427/24229 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/24229
dc.identifier.vancouvercitationBardien S, de Jong G, Schaaf HS, Harris T, Fagan J, Petersen L. Aminoglycoside-induced hearing loss: South Africans at risk. South African Medical Journal. 2009; http://hdl.handle.net/11427/24229.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Otorhinolaryngologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceSouth African Medical Journal
dc.source.urihttp://www.samj.org.za/index.php/samj
dc.titleAminoglycoside-induced hearing loss: South Africans at risk
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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