Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease

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dc.contributor.advisorOpie, Lionel Hen_ZA
dc.contributor.advisorEngel, Mark Een_ZA
dc.contributor.authorMothilal, Shikaren_ZA
dc.date.accessioned2015-08-27T12:30:00Z
dc.date.available2015-08-27T12:30:00Z
dc.date.issued2015en_ZA
dc.description.abstractIn the management of coronary artery disease (CAD) most advances have concerned improvements in catheter-based interventional techniques and complex pharmacotherapy, with an emphasis on time, which unfortunately, cannot always achieved. However, simple measures with reassuring benefit that can be performed even by non-cardiologists have been largely overlooked, or understated. These include limiting reperfusion injury by remote ischaemic conditioning (RIPC), a powerful protective mechanism that can be elicited by the transient occlusion of blood flow to a limb with a blood pressure cuff. More controversially, glucose-insulin-potassium (GIK) therapy in early ST elevation myocardial infarction (STEMI) has the potential to improve outcomes especially when timely restoration of vessel patency is difficult to achieve. This systematic review will evaluate the role of these therapies as adjuncts to revascularisation for treating coronary artery disease either electively or during an acute coronary syndrome. Objectives: To determine if RIPC or GIK therapy for CAD leads to reduced mortality (primary objective), infarct size, cardiac enzyme release or major adverse cardiac and cerebral events (MACCE) and to identify adverse effects associated with RIPC or GIK (secondary objectives).en_ZA
dc.identifier.apacitationMothilal, S. (2015). <i>Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology. Retrieved from http://hdl.handle.net/11427/13785en_ZA
dc.identifier.chicagocitationMothilal, Shikar. <i>"Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology, 2015. http://hdl.handle.net/11427/13785en_ZA
dc.identifier.citationMothilal, S. 2015. Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mothilal, Shikar AB - In the management of coronary artery disease (CAD) most advances have concerned improvements in catheter-based interventional techniques and complex pharmacotherapy, with an emphasis on time, which unfortunately, cannot always achieved. However, simple measures with reassuring benefit that can be performed even by non-cardiologists have been largely overlooked, or understated. These include limiting reperfusion injury by remote ischaemic conditioning (RIPC), a powerful protective mechanism that can be elicited by the transient occlusion of blood flow to a limb with a blood pressure cuff. More controversially, glucose-insulin-potassium (GIK) therapy in early ST elevation myocardial infarction (STEMI) has the potential to improve outcomes especially when timely restoration of vessel patency is difficult to achieve. This systematic review will evaluate the role of these therapies as adjuncts to revascularisation for treating coronary artery disease either electively or during an acute coronary syndrome. Objectives: To determine if RIPC or GIK therapy for CAD leads to reduced mortality (primary objective), infarct size, cardiac enzyme release or major adverse cardiac and cerebral events (MACCE) and to identify adverse effects associated with RIPC or GIK (secondary objectives). DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease TI - Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease UR - http://hdl.handle.net/11427/13785 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/13785
dc.identifier.vancouvercitationMothilal S. Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/13785en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Cardiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleTime is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery diseaseen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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