The effects of a single treatment of an acaricide, Acarosan, and a detergent, Metsan, on Der p 1 allergen levels in the carpets and mattresses of asthmatic children

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dc.contributor.authorManjra, A
dc.contributor.authorBerman, D
dc.contributor.authorToerien, A
dc.contributor.authorWeinberg, E G
dc.contributor.authorPotter, P C
dc.date.accessioned2021-10-08T07:17:52Z
dc.date.available2021-10-08T07:17:52Z
dc.date.issued1994
dc.description.abstractBaseline levels of the house-dust mite allergen, Der p 1, were measured on the carpets and mattresses of 60 pure-mite-sensitive asthmatic children in the Cape Peninsula, by means of an enzyme-linked immunosorbent assay (ELISA). High levels of mite allergens were recorded (range 2-50 micrograms Der p 1/g dust). In order to investigate the efficacy of the application of acaricides to carpets and bedding, 3 groups of 20 children were studied. Carpets and mattresses in group A were treated with a detergent, Metsan (Snowchem), and in group B with Metsan combined with the acaricide, Acarosan (Noristan). Group C was a control group in which no treatment was applied. The level of airway hyperreactivity (PC20) to histamine was measured at the beginning of the study and again 3 months after acaricide treatment. Significant reductions in carpet Der p 1 levels were achieved in group A (22.83 v. 13.26 micrograms Der p 1/g dust; P = 0.04) and group B (21.76 v. 13.26 micrograms Der p 1/g dust; P = 0.01), but mite levels were not reduced in any of the mattresses treated. There was also no improvement in airway hyperreactivity in any of the groups. This study clearly demonstrates that at present it is not possible to reduce Der p 1 antigen levels in mattresses in the Cape Peninsula with the available acaricides, even when one of these is combined with a detergent solution. Until strategies are developed which will significantly reduce Der p 1 levels in the bedding of sensitive individuals, a reduction in ongoing airway inflammation and airway hyperreactivity cannot be expected.
dc.identifier.apacitationManjra, A., Berman, D., Toerien, A., Weinberg, E. G., & Potter, P. C. (1994). The effects of a single treatment of an acaricide, Acarosan, and a detergent, Metsan, on Der p 1 allergen levels in the carpets and mattresses of asthmatic children. <i>South African Medical Journal</i>, 84(5), 278 - 27880. http://hdl.handle.net/11427/34844en_ZA
dc.identifier.chicagocitationManjra, A, D Berman, A Toerien, E G Weinberg, and P C Potter "The effects of a single treatment of an acaricide, Acarosan, and a detergent, Metsan, on Der p 1 allergen levels in the carpets and mattresses of asthmatic children." <i>South African Medical Journal</i> 84, 5. (1994): 278 - 27880. http://hdl.handle.net/11427/34844en_ZA
dc.identifier.citationManjra, A., Berman, D., Toerien, A., Weinberg, E.G. & Potter, P.C. 1994. The effects of a single treatment of an acaricide, Acarosan, and a detergent, Metsan, on Der p 1 allergen levels in the carpets and mattresses of asthmatic children. <i>South African Medical Journal.</i> 84(5):278 - 27880. http://hdl.handle.net/11427/34844en_ZA
dc.identifier.issn0038-2469
dc.identifier.ris TY - Journal Article AU - Manjra, A AU - Berman, D AU - Toerien, A AU - Weinberg, E G AU - Potter, P C AB - Baseline levels of the house-dust mite allergen, Der p 1, were measured on the carpets and mattresses of 60 pure-mite-sensitive asthmatic children in the Cape Peninsula, by means of an enzyme-linked immunosorbent assay (ELISA). High levels of mite allergens were recorded (range 2-50 micrograms Der p 1/g dust). In order to investigate the efficacy of the application of acaricides to carpets and bedding, 3 groups of 20 children were studied. Carpets and mattresses in group A were treated with a detergent, Metsan (Snowchem), and in group B with Metsan combined with the acaricide, Acarosan (Noristan). Group C was a control group in which no treatment was applied. The level of airway hyperreactivity (PC20) to histamine was measured at the beginning of the study and again 3 months after acaricide treatment. Significant reductions in carpet Der p 1 levels were achieved in group A (22.83 v. 13.26 micrograms Der p 1/g dust; P = 0.04) and group B (21.76 v. 13.26 micrograms Der p 1/g dust; P = 0.01), but mite levels were not reduced in any of the mattresses treated. There was also no improvement in airway hyperreactivity in any of the groups. This study clearly demonstrates that at present it is not possible to reduce Der p 1 antigen levels in mattresses in the Cape Peninsula with the available acaricides, even when one of these is combined with a detergent solution. Until strategies are developed which will significantly reduce Der p 1 levels in the bedding of sensitive individuals, a reduction in ongoing airway inflammation and airway hyperreactivity cannot be expected. DA - 1994 DB - OpenUCT DP - University of Cape Town IS - 5 J1 - South African Medical Journal LK - https://open.uct.ac.za PY - 1994 SM - 0038-2469 T1 - The effects of a single treatment of an acaricide, Acarosan, and a detergent, Metsan, on Der p 1 allergen levels in the carpets and mattresses of asthmatic children TI - The effects of a single treatment of an acaricide, Acarosan, and a detergent, Metsan, on Der p 1 allergen levels in the carpets and mattresses of asthmatic children UR - http://hdl.handle.net/11427/34844 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34844
dc.identifier.vancouvercitationManjra A, Berman D, Toerien A, Weinberg EG, Potter PC. The effects of a single treatment of an acaricide, Acarosan, and a detergent, Metsan, on Der p 1 allergen levels in the carpets and mattresses of asthmatic children. South African Medical Journal. 1994;84(5):278 - 27880. http://hdl.handle.net/11427/34844.en_ZA
dc.language.isoeng
dc.publisher.departmentAllergology and Clinical Immunology Unit
dc.publisher.facultyFaculty of Health Sciences
dc.sourceSouth African Medical Journal
dc.source.journalissue5
dc.source.journalvolume84
dc.source.pagination278 - 27880
dc.source.urihttps://dx.doi.org/10.7196/sajs.718
dc.subject.otherAnimals
dc.subject.otherAsthma
dc.subject.otherBeds
dc.subject.otherBenzoates
dc.subject.otherChild
dc.subject.otherChild, Preschool
dc.subject.otherDust
dc.subject.otherFloors and Floorcoverings
dc.subject.otherHumans
dc.subject.otherInsecticides
dc.subject.otherMites
dc.subject.otherProspective Studies
dc.subject.otherTick Control
dc.subject.otherBenzoates
dc.subject.otherDust
dc.subject.otherInsecticides
dc.titleThe effects of a single treatment of an acaricide, Acarosan, and a detergent, Metsan, on Der p 1 allergen levels in the carpets and mattresses of asthmatic children
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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