The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation

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dc.contributor.advisorKatz, Ariehen_ZA
dc.contributor.authorPhillips, Pumza Samanthaen_ZA
dc.date.accessioned2015-01-08T20:00:03Z
dc.date.available2015-01-08T20:00:03Z
dc.date.issued2011en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references (leaves 72-78).en_ZA
dc.description.abstractThe activation of Gonadotropin-releasing hormone receptor (GnRHR) by the GnRH ligand has been shown to mediate antiproliferative effects in extra-pituitary cells and in reproductive cancer cell lines. The GnRHR couples to Gαq in pituitary gonadotropes. However, the GnRHR expressed in reproductive cancer cell lines is thought to couple to Gαi. Recent evidence also suggests that the antiproliferative effects may be mediated via Gαq in these cells. Therefore our study involved determining the role of Gαi in the antiproliferative effects mediated by the GnRHR. The results suggest that the Gαi pathway could play a role in mediating the antiproliferative effects of GnRH.en_ZA
dc.identifier.apacitationPhillips, P. S. (2011). <i>The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry. Retrieved from http://hdl.handle.net/11427/11787en_ZA
dc.identifier.chicagocitationPhillips, Pumza Samantha. <i>"The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2011. http://hdl.handle.net/11427/11787en_ZA
dc.identifier.citationPhillips, P. 2011. The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Phillips, Pumza Samantha AB - The activation of Gonadotropin-releasing hormone receptor (GnRHR) by the GnRH ligand has been shown to mediate antiproliferative effects in extra-pituitary cells and in reproductive cancer cell lines. The GnRHR couples to G&#945;q in pituitary gonadotropes. However, the GnRHR expressed in reproductive cancer cell lines is thought to couple to G&#945;i. Recent evidence also suggests that the antiproliferative effects may be mediated via G&#945;q in these cells. Therefore our study involved determining the role of G&#945;i in the antiproliferative effects mediated by the GnRHR. The results suggest that the G&#945;i pathway could play a role in mediating the antiproliferative effects of GnRH. DA - 2011 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation TI - The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation UR - http://hdl.handle.net/11427/11787 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11787
dc.identifier.vancouvercitationPhillips PS. The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2011 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11787en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Biochemistryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Biochemistryen_ZA
dc.titleThe role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferationen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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