Gonococcal resistance can be viewed productively as part of a syndemic of antimicrobial resistance: an ecological analysis of 30 European countries

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dc.contributor.authorKenyon, Chris
dc.contributor.authorManoharan-Basil, Sheeba S
dc.contributor.authorVan Dijck, Christophe
dc.date.accessioned2020-07-10T11:24:43Z
dc.date.available2020-07-10T11:24:43Z
dc.date.issued2020-06-30
dc.date.updated2020-07-05T04:58:27Z
dc.description.abstractBackground It is unclear how important bystander selection is in the genesis of antimicrobial resistance (AMR) in Neisseria gonorrhoeae. Methods We assessed bystander selection in a novel way. Mixed-effects linear regression was used to assess if country-level prevalence of gonococcal AMR in 30 European countries predicts homologous AMR in other bacteria. The data used was from the European Antimicrobial Resistance Surveillance Network. Results The prevalence of gonococcal ciprofloxacin resistance was found to be positively associated with AMR prevalence in E. coli (coef. 0.52; P = 0.007), Acinetobacter spp. (coef. 0.13; P = 0.044) and Pseudomonas aeruginosa (coef. 0.36; P = 0.020) but not Klebsiella pneumoniae. Azithromycin resistance in N. gonorrhoeae was positively associated with macrolide resistance in Streptococcus pneumoniae (coef. 0.01; P = 0.018). No association was found for cephalosporins. Conclusions Gonococcal AMR is linked to that in other bacteria. This finding is likely explained by high antimicrobial consumption in affected populations and provides additional motivation for strengthening antimicrobial stewardship programs.en_US
dc.identifier.apacitationKenyon, C., Manoharan-Basil, S. S., & Van Dijck, C. (2020). Gonococcal resistance can be viewed productively as part of a syndemic of antimicrobial resistance: an ecological analysis of 30 European countries. <i>Antimicrobial Resistance and Infection Control</i>, 9(1), 91. en_ZA
dc.identifier.chicagocitationKenyon, Chris, Sheeba S Manoharan-Basil, and Christophe Van Dijck "Gonococcal resistance can be viewed productively as part of a syndemic of antimicrobial resistance: an ecological analysis of 30 European countries." <i>Antimicrobial Resistance and Infection Control</i> 9, 1. (2020): 91. en_ZA
dc.identifier.citationKenyon, C., Manoharan-Basil, S.S. & Van Dijck, C. 2020. Gonococcal resistance can be viewed productively as part of a syndemic of antimicrobial resistance: an ecological analysis of 30 European countries. <i>Antimicrobial Resistance and Infection Control.</i> 9(1):91. en_ZA
dc.identifier.ris TY - Journal Article AU - Kenyon, Chris AU - Manoharan-Basil, Sheeba S AU - Van Dijck, Christophe AB - Background It is unclear how important bystander selection is in the genesis of antimicrobial resistance (AMR) in Neisseria gonorrhoeae. Methods We assessed bystander selection in a novel way. Mixed-effects linear regression was used to assess if country-level prevalence of gonococcal AMR in 30 European countries predicts homologous AMR in other bacteria. The data used was from the European Antimicrobial Resistance Surveillance Network. Results The prevalence of gonococcal ciprofloxacin resistance was found to be positively associated with AMR prevalence in E. coli (coef. 0.52; P = 0.007), Acinetobacter spp. (coef. 0.13; P = 0.044) and Pseudomonas aeruginosa (coef. 0.36; P = 0.020) but not Klebsiella pneumoniae. Azithromycin resistance in N. gonorrhoeae was positively associated with macrolide resistance in Streptococcus pneumoniae (coef. 0.01; P = 0.018). No association was found for cephalosporins. Conclusions Gonococcal AMR is linked to that in other bacteria. This finding is likely explained by high antimicrobial consumption in affected populations and provides additional motivation for strengthening antimicrobial stewardship programs. DA - 2020-06-30 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Antimicrobial Resistance and Infection Control KW - Gonorrhoea KW - Neisseria gonorrhoeae KW - Fluoroquinolones KW - Macrolides KW - Antimicrobial resistance KW - Stewardship KW - Antibiotic consumption KW - Bystander selection LK - https://open.uct.ac.za PY - 2020 T1 - Gonococcal resistance can be viewed productively as part of a syndemic of antimicrobial resistance: an ecological analysis of 30 European countries TI - Gonococcal resistance can be viewed productively as part of a syndemic of antimicrobial resistance: an ecological analysis of 30 European countries UR - ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s13756-020-00764-z
dc.identifier.urihttps://hdl.handle.net/11427/32102
dc.identifier.vancouvercitationKenyon C, Manoharan-Basil SS, Van Dijck C. Gonococcal resistance can be viewed productively as part of a syndemic of antimicrobial resistance: an ecological analysis of 30 European countries. Antimicrobial Resistance and Infection Control. 2020;9(1):91. .en_ZA
dc.language.isoenen_US
dc.language.rfc3066en
dc.publisher.departmentDivision of Infectious Disease and HIV Meden_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceAntimicrobial Resistance and Infection Controlen_US
dc.source.journalissue1en_US
dc.source.journalvolume9en_US
dc.source.pagination91en_US
dc.source.urihttps://aricjournal.biomedcentral.com/
dc.subjectGonorrhoeaen_US
dc.subjectNeisseria gonorrhoeaeen_US
dc.subjectFluoroquinolonesen_US
dc.subjectMacrolidesen_US
dc.subjectAntimicrobial resistanceen_US
dc.subjectStewardshipen_US
dc.subjectAntibiotic consumptionen_US
dc.subjectBystander selectionen_US
dc.titleGonococcal resistance can be viewed productively as part of a syndemic of antimicrobial resistance: an ecological analysis of 30 European countriesen_US
dc.typeJournal Articleen_US
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