Human Immunodeficiency Virus? One of nature's greatest evolutionary machines

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dc.contributor.authorMartin, Darren
dc.contributor.authorWilliamson, Carolyn
dc.date.accessioned2017-09-04T12:58:46Z
dc.date.available2017-09-04T12:58:46Z
dc.date.issued2004
dc.date.updated2016-01-14T09:52:49Z
dc.description.abstractTransmission of an HIV-like virus from chimpanzees to humans approximately 80 years ago triggered the worldwide AIDS pandemic. Possessing very high mutation and recombination rates, the descendants of this ancestral virus have evolved greatly. Most of this evolution has been in response to selective pressures imposed by human immune responses and has not provided HIV with any significant new biological characteristics. The continuing diversification of HIV variants is a principal obstruction to controlling the virus with drugs and vaccines.
dc.identifier.apacitationMartin, D., & Williamson, C. (2004). Human Immunodeficiency Virus? One of nature's greatest evolutionary machines. <i>South African Journal of Science</i>, http://hdl.handle.net/11427/25030en_ZA
dc.identifier.chicagocitationMartin, Darren, and Carolyn Williamson "Human Immunodeficiency Virus? One of nature's greatest evolutionary machines." <i>South African Journal of Science</i> (2004) http://hdl.handle.net/11427/25030en_ZA
dc.identifier.citationMartin, D., & Williamson, C. (2004). Human immunodeficiency virus-one of nature's greatest evolutionary machines: pathogen genomics. South African journal of science, 100(9 & 10), p-479.
dc.identifier.ris TY - AU - Martin, Darren AU - Williamson, Carolyn AB - Transmission of an HIV-like virus from chimpanzees to humans approximately 80 years ago triggered the worldwide AIDS pandemic. Possessing very high mutation and recombination rates, the descendants of this ancestral virus have evolved greatly. Most of this evolution has been in response to selective pressures imposed by human immune responses and has not provided HIV with any significant new biological characteristics. The continuing diversification of HIV variants is a principal obstruction to controlling the virus with drugs and vaccines. DA - 2004 DB - OpenUCT DP - University of Cape Town J1 - South African Journal of Science LK - https://open.uct.ac.za PB - University of Cape Town PY - 2004 T1 - Human Immunodeficiency Virus? One of nature's greatest evolutionary machines TI - Human Immunodeficiency Virus? One of nature's greatest evolutionary machines UR - http://hdl.handle.net/11427/25030 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/25030
dc.identifier.vancouvercitationMartin D, Williamson C. Human Immunodeficiency Virus? One of nature's greatest evolutionary machines. South African Journal of Science. 2004; http://hdl.handle.net/11427/25030.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Virologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceSouth African Journal of Science
dc.source.urihttp://www.sajs.co.za/
dc.titleHuman Immunodeficiency Virus? One of nature's greatest evolutionary machines
dc.typeJournal Article
uct.type.filetypeText
uct.type.filetypeImage
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