Emergence of a peak in early infant mortality due to HIV/AIDS in South Africa

dc.contributor.authorBourne, David E
dc.contributor.authorThompson, MaryLou
dc.contributor.authorBrodya, Linnea L
dc.contributor.authorCotton, Mark
dc.contributor.authorDraper, Beverly
dc.contributor.authorLaubscher, Ria
dc.contributor.authorAbdullah, M Fareed
dc.contributor.authorMyers, Jonny E
dc.date.accessioned2018-05-08T09:06:42Z
dc.date.available2018-05-08T09:06:42Z
dc.date.issued2009
dc.date.updated2016-01-22T08:09:00Z
dc.description.abstractObjectives: South Africa has among the highest levels of HIV prevalence in the world. Our objectives are to describe the distribution of South African infant and child mortality by age at fine resolution, to identify any trends over recent time and to examine these trends for HIV-associated and non HIV-associated causes of mortality. Methods: A retrospective review of vital registration data was conducted. All registered postneonatal deaths under 1 year of age in South Africa for the period 1997–2002 were analysed by age in months using a generalized linear model with a log link and Poisson family. Results: Postneonatal mortality increased each year over the period 1997–2002. A peak in HIV-related deaths was observed, centred at 2–3 months of age, rising monotonically over time. Conclusion: We interpret the peak in mortality at 2–3 months as an indicator for paediatric AIDS in a South African population with high HIV prevalence and where other causes of death are not sufficiently high to mask HIV effects. Intrauterine and intrapartum infection may contribute to this peak. It is potentially a useful surveillance tool, not requiring an exact cause of death. The findings also illustrate the need for early treatment of mother and child in settings with very high HIV prevalence.
dc.identifierhttp://dx.doi.org/10.1097/QAD.0b013e32831c54bd
dc.identifier.apacitationBourne, D. E., Thompson, M., Brodya, L. L., Cotton, M., Draper, B., Laubscher, R., ... Myers, J. E. (2009). Emergence of a peak in early infant mortality due to HIV/AIDS in South Africa. <i>AIDS</i>, http://hdl.handle.net/11427/28006en_ZA
dc.identifier.chicagocitationBourne, David E, MaryLou Thompson, Linnea L Brodya, Mark Cotton, Beverly Draper, Ria Laubscher, M Fareed Abdullah, and Jonny E Myers "Emergence of a peak in early infant mortality due to HIV/AIDS in South Africa." <i>AIDS</i> (2009) http://hdl.handle.net/11427/28006en_ZA
dc.identifier.citationBourne, D. E., Thompson, M., Brody, L. L., Cotton, M., Draper, B., Laubscher, R., ... & Myers, J. E. (2009). Emergence of a peak in early infant mortality due to HIV/AIDS in South Africa. Aids, 23(1), 101-106.
dc.identifier.ris TY - AU - Bourne, David E AU - Thompson, MaryLou AU - Brodya, Linnea L AU - Cotton, Mark AU - Draper, Beverly AU - Laubscher, Ria AU - Abdullah, M Fareed AU - Myers, Jonny E AB - Objectives: South Africa has among the highest levels of HIV prevalence in the world. Our objectives are to describe the distribution of South African infant and child mortality by age at fine resolution, to identify any trends over recent time and to examine these trends for HIV-associated and non HIV-associated causes of mortality. Methods: A retrospective review of vital registration data was conducted. All registered postneonatal deaths under 1 year of age in South Africa for the period 1997–2002 were analysed by age in months using a generalized linear model with a log link and Poisson family. Results: Postneonatal mortality increased each year over the period 1997–2002. A peak in HIV-related deaths was observed, centred at 2–3 months of age, rising monotonically over time. Conclusion: We interpret the peak in mortality at 2–3 months as an indicator for paediatric AIDS in a South African population with high HIV prevalence and where other causes of death are not sufficiently high to mask HIV effects. Intrauterine and intrapartum infection may contribute to this peak. It is potentially a useful surveillance tool, not requiring an exact cause of death. The findings also illustrate the need for early treatment of mother and child in settings with very high HIV prevalence. DA - 2009 DB - OpenUCT DP - University of Cape Town J1 - AIDS LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Emergence of a peak in early infant mortality due to HIV/AIDS in South Africa TI - Emergence of a peak in early infant mortality due to HIV/AIDS in South Africa UR - http://hdl.handle.net/11427/28006 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/28006
dc.identifier.vancouvercitationBourne DE, Thompson M, Brodya LL, Cotton M, Draper B, Laubscher R, et al. Emergence of a peak in early infant mortality due to HIV/AIDS in South Africa. AIDS. 2009; http://hdl.handle.net/11427/28006.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceAIDS
dc.source.urihttp://www.ovid.com/site/index.jsp
dc.subject.otherdemography
dc.subject.othermortality
dc.subject.otherpaediatric AIDS
dc.subject.otherpostneonatal
dc.subject.otherSouth Africa
dc.titleEmergence of a peak in early infant mortality due to HIV/AIDS in South Africa
dc.typeJournal Article
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uct.type.filetypeText
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