An electrophoretic study of fetal mouse brain proteins after in vivo exposure to phenytoin and disulfiram

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dc.contributor.advisorFolb, Peter Ien_ZA
dc.contributor.authorHeiberg, Ludvigen_ZA
dc.date.accessioned2018-01-31T13:51:15Z
dc.date.available2018-01-31T13:51:15Z
dc.date.issued1990en_ZA
dc.description.abstractAlthough there have been two-dimensional electrophoretic studies on fetal brain tissue (for instance, Yoshida and Takahashi, 1980), the emphasis in most of this work has been on developmental changes in protein expression, and not on the effects that drugs have on fetal brain protein complement. Klose and co-workers (1977) did an early study using two-dimensional gel electrophoresis to determine the effects of various teratogens on whole embryos. No protein changes were found and that line of research was not continued. In this study two-dimensional gel electrophoresis is extensively used, in the belief that the usefulness of this technique to experimental teratology has not been fully evaluated. It is reasonable to suppose that a central nervous system teratogen administered during critical periods of susceptibility will led to perturbations of orderly brain development, and that these perturbations will be reflected as changes to the protein complement. The total brain protein complement of mice that have been exposed to drugs in utero will therefore be analysed, in the hope that any inductions or deletions of proteins as a result of drug exposure may provide a clue to the molecular events underlying drug injury to the fetus.en_ZA
dc.identifier.apacitationHeiberg, L. (1990). <i>An electrophoretic study of fetal mouse brain proteins after in vivo exposure to phenytoin and disulfiram</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology. Retrieved from http://hdl.handle.net/11427/27187en_ZA
dc.identifier.chicagocitationHeiberg, Ludvig. <i>"An electrophoretic study of fetal mouse brain proteins after in vivo exposure to phenytoin and disulfiram."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 1990. http://hdl.handle.net/11427/27187en_ZA
dc.identifier.citationHeiberg, L. 1990. An electrophoretic study of fetal mouse brain proteins after in vivo exposure to phenytoin and disulfiram. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Heiberg, Ludvig AB - Although there have been two-dimensional electrophoretic studies on fetal brain tissue (for instance, Yoshida and Takahashi, 1980), the emphasis in most of this work has been on developmental changes in protein expression, and not on the effects that drugs have on fetal brain protein complement. Klose and co-workers (1977) did an early study using two-dimensional gel electrophoresis to determine the effects of various teratogens on whole embryos. No protein changes were found and that line of research was not continued. In this study two-dimensional gel electrophoresis is extensively used, in the belief that the usefulness of this technique to experimental teratology has not been fully evaluated. It is reasonable to suppose that a central nervous system teratogen administered during critical periods of susceptibility will led to perturbations of orderly brain development, and that these perturbations will be reflected as changes to the protein complement. The total brain protein complement of mice that have been exposed to drugs in utero will therefore be analysed, in the hope that any inductions or deletions of proteins as a result of drug exposure may provide a clue to the molecular events underlying drug injury to the fetus. DA - 1990 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1990 T1 - An electrophoretic study of fetal mouse brain proteins after in vivo exposure to phenytoin and disulfiram TI - An electrophoretic study of fetal mouse brain proteins after in vivo exposure to phenytoin and disulfiram UR - http://hdl.handle.net/11427/27187 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/27187
dc.identifier.vancouvercitationHeiberg L. An electrophoretic study of fetal mouse brain proteins after in vivo exposure to phenytoin and disulfiram. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 1990 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/27187en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Clinical Pharmacologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherDisulfiram - Toxicologyen_ZA
dc.subject.otherPhenytoin - Toxicologyen_ZA
dc.subject.otherFetus - Effect of drugs onen_ZA
dc.subject.otherTeratogenic agentsen_ZA
dc.subject.otherDisulfiram - Toxicologyen_ZA
dc.subject.otherPhenytoin - toxicityen_ZA
dc.subject.otherFetal proteins - drug effectsen_ZA
dc.subject.otherFetus - Drug effectsen_ZA
dc.subject.otherTeraen_ZA
dc.titleAn electrophoretic study of fetal mouse brain proteins after in vivo exposure to phenytoin and disulfiramen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMSc (Med)en_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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