Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants

Simple item page
dc.contributor.authorHolder, Bethen_ZA
dc.contributor.authorMiles, David J Cen_ZA
dc.contributor.authorKaye, Steveen_ZA
dc.contributor.authorCrozier, Sarahen_ZA
dc.contributor.authorMohammed, Nuredin Ibrahimen_ZA
dc.contributor.authorDuah, Nancy Oen_ZA
dc.contributor.authorRoberts, Elishiaen_ZA
dc.contributor.authorOjuola, Olubukolaen_ZA
dc.contributor.authorPalmero, Melba Sen_ZA
dc.contributor.authorTouray, Ebrima Sen_ZA
dc.date.accessioned2016-01-11T06:52:13Z
dc.date.available2016-01-11T06:52:13Z
dc.date.issued2010en_ZA
dc.description.abstractBACKGROUND: Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are persistent herpesviruses that have various immunomodulatory effects on their hosts. Both viruses are usually acquired in infancy in Sub-Saharan Africa, a region where childhood vaccines are less effective than in high income settings. To establish whether there is an association between these two observations, we tested the hypothesis that infection with one or both viruses modulate antibody responses to the T-cell independent meningococcal polysaccharide vaccine and the T-cell dependent measles vaccines. METHODOLOGY/PRINCIPAL FINDINGS: Infection with EBV and CMV was diagnosed by the presence of virus-specific IgM in the peripheral blood or by the presence of IgG at higher levels than that found in umbilical cord blood. Anti-meningococcus IgG and IgM were quantified by ELISA. Anti-measles antibody responses were quantified by haemagglutinin antibody inhibition assay. Infants infected with EBV had reduced IgG and IgM antibody responses to meningococcal polysaccharides and to measles vaccine. Infection with CMV alone predicted no changes in the response to meningococcal polysaccharide. While CMV alone had no discernable effect on the antibody response to measles, the response of infants infected with both CMV and EBV was similar to that of infants infected with neither, suggesting that the effects of CMV infection countered the effects of EBV on measles antibody responses. CONCLUSIONS: The results of this exploratory study indicate that infection with EBV is associated with reduced antibody responses to polysaccharides and to measles vaccine, but suggest that the response to T-cell dependent antigens such as measles haemagglutinin may be restored by infection with CMV.en_ZA
dc.identifier.apacitationHolder, B., Miles, D. J. C., Kaye, S., Crozier, S., Mohammed, N. I., Duah, N. O., ... Touray, E. S. (2010). Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants. <i>PLoS One</i>, http://hdl.handle.net/11427/16259en_ZA
dc.identifier.chicagocitationHolder, Beth, David J C Miles, Steve Kaye, Sarah Crozier, Nuredin Ibrahim Mohammed, Nancy O Duah, Elishia Roberts, Olubukola Ojuola, Melba S Palmero, and Ebrima S Touray "Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants." <i>PLoS One</i> (2010) http://hdl.handle.net/11427/16259en_ZA
dc.identifier.citationHolder, B., Miles, D. J., Kaye, S., Crozier, S., Mohammed, N. I., Duah, N. O., ... & Waight, P. (2010). Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants. PloS one, 5(11), e14013. doi:10.1371/journal.pone.0014013en_ZA
dc.identifier.ris TY - Journal Article AU - Holder, Beth AU - Miles, David J C AU - Kaye, Steve AU - Crozier, Sarah AU - Mohammed, Nuredin Ibrahim AU - Duah, Nancy O AU - Roberts, Elishia AU - Ojuola, Olubukola AU - Palmero, Melba S AU - Touray, Ebrima S AB - BACKGROUND: Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are persistent herpesviruses that have various immunomodulatory effects on their hosts. Both viruses are usually acquired in infancy in Sub-Saharan Africa, a region where childhood vaccines are less effective than in high income settings. To establish whether there is an association between these two observations, we tested the hypothesis that infection with one or both viruses modulate antibody responses to the T-cell independent meningococcal polysaccharide vaccine and the T-cell dependent measles vaccines. METHODOLOGY/PRINCIPAL FINDINGS: Infection with EBV and CMV was diagnosed by the presence of virus-specific IgM in the peripheral blood or by the presence of IgG at higher levels than that found in umbilical cord blood. Anti-meningococcus IgG and IgM were quantified by ELISA. Anti-measles antibody responses were quantified by haemagglutinin antibody inhibition assay. Infants infected with EBV had reduced IgG and IgM antibody responses to meningococcal polysaccharides and to measles vaccine. Infection with CMV alone predicted no changes in the response to meningococcal polysaccharide. While CMV alone had no discernable effect on the antibody response to measles, the response of infants infected with both CMV and EBV was similar to that of infants infected with neither, suggesting that the effects of CMV infection countered the effects of EBV on measles antibody responses. CONCLUSIONS: The results of this exploratory study indicate that infection with EBV is associated with reduced antibody responses to polysaccharides and to measles vaccine, but suggest that the response to T-cell dependent antigens such as measles haemagglutinin may be restored by infection with CMV. DA - 2010 DB - OpenUCT DO - 10.1371/journal.pone.0014013 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants TI - Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants UR - http://hdl.handle.net/11427/16259 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16259
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0014013
dc.identifier.vancouvercitationHolder B, Miles DJC, Kaye S, Crozier S, Mohammed NI, Duah NO, et al. Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants. PLoS One. 2010; http://hdl.handle.net/11427/16259.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentSouth African Tuberculosis Vaccine Initiative (SATVI)en_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2010 Holder et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherInfantsen_ZA
dc.subject.otherAntibodiesen_ZA
dc.subject.otherAntibody responseen_ZA
dc.subject.otherNeisseria meningitidisen_ZA
dc.subject.otherVaccinesen_ZA
dc.subject.otherMeningococcal diseaseen_ZA
dc.subject.otherEpstein-Barr virusen_ZA
dc.subject.otherCytomegalovirus infectionen_ZA
dc.titleEpstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infantsen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Holder_Epstein_Barr_Virus_2010.pdf
Size:
246.42 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles