Cardiomyopathy in Africa: heredity versus environment

dc.contributor.authorMayosi, Bongani M
dc.contributor.authorSomers, Krishna
dc.date.accessioned2017-06-28T09:13:50Z
dc.date.available2017-06-28T09:13:50Z
dc.date.issued2007
dc.date.updated2016-01-12T07:32:04Z
dc.description.abstractUnlike other parts of the world in which cardiomyopathy is rare, heart muscle disease is endemic in Africa. The major forms of cardiomyopathy in Africa are dilated cardiomyopathy (DCM) and endomyocardial fibrosis (EMF). Whereas DCM is a major cause of heart failure throughout the continent, EMF is restricted to the tropical regions of East, Central, and West Africa. Although epidemiological studies are lacking, hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy seem to have characteristics similar to those of other populations elsewhere in the world. Recent advances in the genetic analysis of DCM in other parts of the world indicate that it is a genetically heterogeneous disorder in which some cases have a Mendelian cause and others have a non-genetic or multifactorial cause. This heterogeneous pattern of inheritance has been confirmed in small studies that have been conducted so far in Africa. The advent of human immunodeficiency virus infection and its association with cardiomyopathy has emphasised the role of inflammatory agents in the pathogenesis of DCM. By contrast with DCM in which some cases have major genetic contributions, there is scanty evidence for the role of genetic factors in the aetiology of EMF. Although the pathogenesis of EMF is not fully understood, it appears that the conditioning factor may be geography (in its widest sense, to include climate and socio-economic status), the triggering factor may be an as yet unidentified infective agent, and the perpetuating factor may be eosinophilia. There is a need for renewed effort to identify genetic and non-genetic factors in EMF and other forms of heart muscle disease that are prevalent on the continent of Africa.
dc.identifier.apacitationMayosi, B. M., & Somers, K. (2007). Cardiomyopathy in Africa: heredity versus environment. <i>Cardiovascular Journal of Africa</i>, http://hdl.handle.net/11427/24657en_ZA
dc.identifier.chicagocitationMayosi, Bongani M, and Krishna Somers "Cardiomyopathy in Africa: heredity versus environment." <i>Cardiovascular Journal of Africa</i> (2007) http://hdl.handle.net/11427/24657en_ZA
dc.identifier.citationMayosi, B. M., & Somers, K. (2007). Cardiomyopathy in Africa: heredity versus environment: review article. Cardiovascular journal of Africa, 18(3), 175-179.
dc.identifier.ris TY - Journal Article AU - Mayosi, Bongani M AU - Somers, Krishna AB - Unlike other parts of the world in which cardiomyopathy is rare, heart muscle disease is endemic in Africa. The major forms of cardiomyopathy in Africa are dilated cardiomyopathy (DCM) and endomyocardial fibrosis (EMF). Whereas DCM is a major cause of heart failure throughout the continent, EMF is restricted to the tropical regions of East, Central, and West Africa. Although epidemiological studies are lacking, hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy seem to have characteristics similar to those of other populations elsewhere in the world. Recent advances in the genetic analysis of DCM in other parts of the world indicate that it is a genetically heterogeneous disorder in which some cases have a Mendelian cause and others have a non-genetic or multifactorial cause. This heterogeneous pattern of inheritance has been confirmed in small studies that have been conducted so far in Africa. The advent of human immunodeficiency virus infection and its association with cardiomyopathy has emphasised the role of inflammatory agents in the pathogenesis of DCM. By contrast with DCM in which some cases have major genetic contributions, there is scanty evidence for the role of genetic factors in the aetiology of EMF. Although the pathogenesis of EMF is not fully understood, it appears that the conditioning factor may be geography (in its widest sense, to include climate and socio-economic status), the triggering factor may be an as yet unidentified infective agent, and the perpetuating factor may be eosinophilia. There is a need for renewed effort to identify genetic and non-genetic factors in EMF and other forms of heart muscle disease that are prevalent on the continent of Africa. DA - 2007 DB - OpenUCT DP - University of Cape Town J1 - Cardiovascular Journal of Africa LK - https://open.uct.ac.za PB - University of Cape Town PY - 2007 T1 - Cardiomyopathy in Africa: heredity versus environment TI - Cardiomyopathy in Africa: heredity versus environment UR - http://hdl.handle.net/11427/24657 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/24657
dc.identifier.vancouvercitationMayosi BM, Somers K. Cardiomyopathy in Africa: heredity versus environment. Cardiovascular Journal of Africa. 2007; http://hdl.handle.net/11427/24657.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceCardiovascular Journal of Africa
dc.source.urihttp://www.cvja.co.za/archive.php
dc.titleCardiomyopathy in Africa: heredity versus environment
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Mayosi_Cardiomyopathy_2007.pdf
Size:
219.4 KB
Format:
Adobe Portable Document Format
Description:
License bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.72 KB
Format:
Item-specific license agreed upon to submission
Description:
Collections