Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation

Master Thesis

2012

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http://hdl.handle.net/11427/3370
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thesis_hsf_2012_centner_c.pdf (2.7 MB)
Authors
Centner, Chad
Supervisors
Heckmann, Jeannine
Dandara, Collet
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University of Cape Town

Department
Department of Medicine
Faculty
Faculty of Health Sciences
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Abstract
Both human immunodeficiency virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced peripheral neuropathy (INH-PN). In co-infection with and co-treatment for HIV/TB, DSP risk is increased. Factors driving this risk may be vitamin B6 deficiency and slow metabolism of INH mediated by N-acetyltransferase 2 (NAT2) acetylation, both known risk
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Medicine

Reference:

Centner, C. 2012. Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation. University of Cape Town.

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