Browsing by Subject "systemic autoimmune disorder"

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    Abnormal myocardial perfusion correlates with impaired systolic strain and diastolic strain rate in systemic lupus erythematosus: a cardiovascular magnetic resonance study
    (BioMed Central Ltd, 2015) Ntusi, Ntobeko; Sever, Emily; Lockey, Joseph; Francis, Jane; Piechnik, Stefan; Ferreira, Vanessa; Matthews, Paul; Wordsworth, Paul; Neubauer, Stefan; Karamitsos, Theodoros
    Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder that commonly affects the heart, resulting in a 7 to 9 times greater incidence of cardiovascular disease (CVD) in SLE patients compared to healthy controls. Female patients with SLE between 35 and 44 years old have an incidence of myocardial infarction over 50 times greater than that observed in the Framingham cohort. The clinical utility of cardiovascular magnetic resonance (CMR) first-pass perfusion for assessment of myocardial ischaemia is well-established. We hypothesised that CMR including stress first-pass perfusion would be able to detect coronary microvascular disease and subtle functional abnormalities in SLE and aimed to detect myocardial ischaemia in SLE using adenosine stress perfusion CMR.