Browsing by Subject "immunization"

Now showing 1 - 3 of 3
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    Congenital rubella: Is it nearly time to take action?
    (Health and Medical Publishing Group, 2012) Boshoff, L; Tooke, L
    Congenital rubella syndrome (CRS) is a rare but potentially debilitating disease with lifelong consequences. Although there is no cure, it is almost completely preventable by an effective immunisation programme. We present two confirmed cases of CRS diagnosed in the neonatal unit at Groote Schuur Hospital in 2011 and discuss aspects of the disease and its prevention.
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    Induction of HIV-1 Gag-specific memory T cells in Chacma baboons by MVA prime and VLP boost vaccine regimen
    (BioMed Central Ltd, 2012) Singh, V; Chege, G; Shephard, E; Williamson, A
    We previously reported induction of HIV-specific responses in Chacma baboons following immunization with SAAVI MVA-C (MVA) and HIV-1 Pr55 Gag virus-like particles (VLPs) in a prime-boost vaccination strategy. In the current study, we characterised the vaccine specific memory T cells by flow cytometry.
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    Predictors of COVID-19 Vaccine Hesitancy in South African Local Communities: The VaxScenes Study
    (Multidisciplinary Digital Publishing Institute, 2022-02-25) Katoto, Patrick D M C; Parker, Saahier; Coulson, Nancy; Pillay, Nirvana; Cooper, Sara; Jaca, Anelisa; Mavundza, Edison; Houston, Gregory; Groenewald, Candice; Essack, Zaynab; Simmonds, Jane; Shandu, Londiwe Deborah; Couch, Marilyn; Khuzwayo, Nonkululeko; Ncube, Nobukhosi; Bhengu, Phelele; Rooyen, Heidi van; Wiysonge, Charles Shey
    South Africa launched a mass COVID-19 vaccination campaign in May 2021, targeting 40 million adults. Understanding predictors of COVID-19 vaccine intentions was required to achieve this goal. We conducted a population-based survey in June–July 2021 using the WHO Behavioral and Social Drivers (BeSD) of COVID-19 Vaccination tool to determine predictors of vaccine hesitancy, defined as intention to refuse or uncertainty whether to accept COVID-19 vaccination. There were 1193 participants, mean age 39 (standard deviation 15) years, and 53% women, of whom 58% trusted information provided by healthcare workers and 32% were vaccine hesitant. Independent predictors of vaccine hesitancy included concerns about side effects (odds ratio (OR) 11.41; 95% confidence interval (CI) 3.5–50.80), lack of access to the online vaccine registration platform (OR 4.75; CI 2.15–10.37), distrust of government (OR 3.0; CI 1.33–6.77), belief in conspiracy theories (OR 3.01; CI 1.32–6.77), having no monthly income (OR 1.84; CI 1.12–3.07), and depending on someone else to make vaccination decision (OR 2.47; CI 1.06–5.77). We identified modifiable predictors of vaccine hesitancy at the start of South Africa’s COVID-19 vaccination rollout. These factors should be addressed by different stakeholders involved in the national immunization program through tailored communication and other effective strategies that increase vaccine literacy, reach low-income households, and engender confidence in government.