Browsing by Subject "drug"

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    Open Access
    Current trends in drug treatment of obsessive–compulsive disorder
    (2010) Decloedt, Eric
    This article aims to highlight current trends in the pharmacologic management of obsessive–compulsive disorder (OCD). A systematic search of the electronic database MEDLINE was conducted. The first case report of clomipramine efficacy in the management OCD more than 40 years ago gave new hope for the treatment of this debilitating disorder. Selective serotonin reuptake inhibitors (SSRIs) proved to have a similar efficacy profile compared with clomipramine but had a superior tolerability profile. While many patients with OCD respond to SSRIs or clomipramine, the treatment of those with refractory OCD remains challenging. Different augmentation agents in treatment-resistant OCD have been explored, with antipsychotic agents having the largest supporting evidence base. Nevertheless, new pharmacologic treatment options are required and are under investigation.
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    Open Access
    Synthesis and evaluation of bioluminescent probes as tools for anticancer drug discovery
    (2026) Fredericks, Maryam; Jardine, Mogamat
    Luciferins are a class of small, light-emitting molecules that produce visible light through an oxidation reaction catalysed by luciferase enzymes. This bioluminescent system, when combined with CCD camera technologies, has enabled groundbreaking advances in measuring mammalian gene expression, protein–protein interactions, biochemical labelling, and small molecule dynamics. Among the luciferins, D-luciferin—originally isolated from the American firefly Photinus pyralis—is the most extensively studied. Synthetic analogues of D-luciferin have become increasingly important due to their incorporation into a wide range of commercially available assay kits, where they serve as sensitive reporters in both in vitro and in vivo applications. This thesis focuses on the development of improved synthetic methods for D-thioluciferin, C6-substituted analogues, and aza-derivatives of D-luciferin, the latter enabling the design of novel caged bioluminescent probes for advanced molecular imaging.