Browsing by Subject "Gastrins"

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    Aspects of structure-activity relationships and physiology of gastrin and related peptides
    (1978) Napier, Beverley Jean; Vinik, Aaron I
    When, in 1973, I embarked upon this study, the hormone gastrin seemed a suitable hormone to study with regard to investigation of structure-activity relationships and physiology of a peptide hormone. Gastrin was best known at that stage as a linear peptide comprising 17 amino acids, which was stable at room temperature and was resistant to degradation by vigorous treatments such as boiling {Gregory and Tracy, 1964; Berson and Yalow, 1971; Yalow and Berson, 1972) and pH extremes (Piszkiewicz, 1974). Such a molecule could thus be studied at room temperature, using conventional biochemical techniques, without the need for any special precautions to preserve its integrity.
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    Quantitative cytochemical studies of acid secretagogue effects on the carbonic anhydrase activity of gastric parietal cell sections
    (1982) Klaff, Leslie Joseph; Vinik, Aaron I; Jackson, W P U; Isaacson, Leon
    This thesis presents work designed to study the effects of acid secretagogues upon the parietal cell, in order to gain a greater understanding of their modes of action, and interaction and the role of circulating secretagogues in the mediation of parietal cell function, with the aim of increasing the understanding of the pathophysiology of the world-wide problem of peptic ulcer disease.