Browsing by Subject "Computer Systems"

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    H3ABioNet, a sustainable pan-African bioinformatics network for human heredity and health in Africa
    (2016) Mulder, Nicola J; Adebiyi, Ezekiel; Alami, Raouf; Benkahla, Alia; Brandful, James; Doumbia, Seydou; Everett, Dean; Fadlelmola, Faisal M; Gaboun, Fatima; Gaseitsiwe, Simani; Ghazal, Hassan; Hazelhurst, Scott; Hide, Winston; Ibrahimi, Azeddine; Jaufeerally Fakim, Yasmina; Jongeneel, C Victor; Joubert, Fourie; Kassim, Samar; Kayondo, Jonathan; Kumuthini, Judit; Lyantagaye, Sylvester; Makani, Julie; Mansour Alzohairy, Ahmed; Masiga, Daniel; Moussa, Ahmed; Nash, Oyekanmi; Ouwe Missi Oukem-Boyer, Odile; Owusu-Dabo, Ellis; Panji, Sumir; Patterton, Hugh; Radouani, Fouzia; Sadki, Khalid
    The application of genomics technologies to medicine and biomedical research is increasing in popularity, made possible by new high-throughput genotyping and sequencing technologies and improved data analysis capabilities. Some of the greatest genetic diversity among humans, animals, plants, and microbiota occurs in Africa, yet genomic research outputs from the continent are limited. The Human Heredity and Health in Africa (H3Africa) initiative was established to drive the development of genomic research for human health in Africa, and through recognition of the critical role of bioinformatics in this process, spurred the establishment of H3ABioNet, a pan-African bioinformatics network for H3Africa. The limitations in bioinformatics capacity on the continent have been a major contributory factor to the lack of notable outputs in high-throughput biology research. Although pockets of high-quality bioinformatics teams have existed previously, the majority of research institutions lack experienced faculty who can train and supervise bioinformatics students. H3ABioNet aims to address this dire need, specifically in the area of human genetics and genomics, but knock-on effects are ensuring this extends to other areas of bioinformatics. Here, we describe the emergence of genomics research and the development of bioinformatics in Africa through H3ABioNet.
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    Organization of industrial control computers
    (1976) Rodd, Michael Godfrey; Enslin, NC de V; MacGregor, Ken
    The efficient use of industrial control computers is recognized as an organizational problem akin to the traffic-switching problem in communications. A systematic approach to this problem is proposed, based on theory developed for the handling of telephone traffic. The application of the approach indicates that it is necessary to re-evaluate traditional hardware/software relationships. A change in these relationships is desirable, since multi-programmed computers spend too much time in handling their own organization. This situation is compounded in time-critical industrial process-control applications. It is proposed that the solution lies in the use of a flexible hardware operating system, working in close relationship with a conventional minicomputer. The unit proposed to implement this function, termed a microcontroller, makes use of the new bipolar microprocessor elements and provides a high-speed, flexible control unit, adaptable to user requirements. To retain a high degree of flexibility the microcontroller is microprogrammable. In essence, the unit executes the principal functions of a real-time operating system, acts as a pre-processor for all incoming requests, and ensures a high rate of task-switching. This system is applied to a series of configurations, each selected to demonstrate, quantitatively, the value of the technique in real applications. Comparisons are made between real-time control configurations based on the software-implemented approach and the identical configurations based on this system. The proposed strategy is shown to result in a better and more economical industrial controller. The wider implication for any aspect of organization is that "bigger" is not necessarily "better". Successful management implies effective use of facilities, rather than a proliferating structure.