Browsing by Subject "Behaviour"
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- ItemOpen AccessThe research landscape of tuberous sclerosis complex–associated neuropsychiatric disorders (TAND)—a comprehensive scoping review(2022-02-13) Vanclooster, Stephanie; Bissell, Stacey; van Eeghen, Agnies M; Chambers, Nola; De Waele, Liesbeth; Byars, Anna W; Capal, Jamie K; Cukier, Sebastián; Davis, Peter; Flinn, Jennifer; Gardner-Lubbe, Sugnet; Gipson, Tanjala; Heunis, Tosca-Marie; Hook, Dena; Kingswood, J C; Krueger, Darcy A; Kumm, Aubrey J; Sahin, Mustafa; Schoeters, Eva; Smith, Catherine; Srivastava, Shoba; Takei, Megumi; Waltereit, Robert; Jansen, Anna C; de Vries, Petrus JBackground Tuberous sclerosis complex (TSC)–associated neuropsychiatric disorders (TAND) is an umbrella term for the behavioural, psychiatric, intellectual, academic, neuropsychological and psychosocial manifestations of TSC. Although TAND affects 90% of individuals with TSC during their lifetime, these manifestations are relatively under-assessed, under-treated and under-researched. We performed a comprehensive scoping review of all TAND research to date (a) to describe the existing TAND research landscape and (b) to identify knowledge gaps to guide future TAND research. Methods The study was conducted in accordance with stages outlined within the Arksey and O’Malley scoping review framework. Ten research questions relating to study characteristics, research design and research content of TAND levels and clusters were examined. Results Of the 2841 returned searches, 230 articles published between 1987 and 2020 were included (animal studies = 30, case studies = 47, cohort studies = 153), with more than half published since the term TAND was coined in 2012 (118/230; 51%). Cohort studies largely involved children and/or adolescents (63%) as opposed to older adults (16%). Studies were represented across 341 individual research sites from 45 countries, the majority from the USA (89/341; 26%) and the UK (50/341; 15%). Only 48 research sites (14%) were within low–middle income countries (LMICs). Animal studies and case studies were of relatively high/high quality, but cohort studies showed significant variability. Of the 153 cohort studies, only 16 (10%) included interventions. None of these were non-pharmacological, and only 13 employed remote methodologies (e.g. telephone interviews, online surveys). Of all TAND clusters, the autism spectrum disorder–like cluster was the most widely researched (138/230; 60%) and the scholastic cluster the least (53/200; 27%). Conclusions Despite the recent increase in TAND research, studies that represent participants across the lifespan, LMIC research sites and non-pharmacological interventions were identified as future priorities. The quality of cohort studies requires improvement, to which the use of standardised direct behavioural assessments may contribute. In human studies, the academic level in particular warrants further investigation. Remote technologies could help to address many of the TAND knowledge gaps identified.
- ItemOpen AccessSneaky African fig wasps that oviposit through holes drilled by other species(2009) Compton, Stephen G; Van Noort, Simon; McLeish, Michael; Deeble, Mark; Stone, VictoriaWatshamiella Wiebes species (Hymenoptera: Chalcidoidea: Pteromalidae: Sycoryctinae) were observed to engage, monitor and subsequently use oviposition holes made by other parasitoid fig wasp genera (Apocrypta Coquerel and Sycoryctes Mayr) to oviposit into host figs (Moraceae, Ficus) through the fig wall. They may be inquilines, klepto-parasitoids, or hyper-parasitoids; however, further biological investigations of larval diet are required to establish their life history strategy. Watshamiella species are morphologically robust, with enlarged fore femora and tibia, and aggressively interact with other fig wasps and ants. Our observations contribute towards unravelling the complex suite of behavioural adaptations and interactions involved in the community ecology of the obligate mutualism that exists between fig wasps and their host figs.
- ItemOpen AccessThe adverse health effects associated with drought in Africa: working towards developing a vulnerability index(2020) Asmall, Taherah; Dalvie, Aqiel; Abrams, AmberAfrica is uniquely vulnerable to the occurrence of drought. A rise in temperatures over Southern Africa occurs at almost twice that of the global rate. South Africa has begun to experience an increase in the frequency of drought, particularly in the Western and Eastern Cape. Droughts are associated with several health effects. The direct and indirect risks of climate change to human health have become a global concern. The most recent systematic review available on the adverse health effects associated with drought was published in 2013, and as such, an up-to-date review focusing on Africa is needed to inform a Cape Town specific health vulnerability index. This study aims to provide a review of available research exploring the association between drought and adverse health effects in Africa. The rationale for this study is to provide a solid research foundation from which a drought-specific health vulnerability index for Cape Town can be developed. A narrative review of original studies and published reviews was conducted. An extensive electronic literature search was performed using a combination of keywords, Medical Subject Heading (MeSH) terms and free text words. The Critical Appraisal Toolkit (CAT) was used to assess the quality of included studies. A total of 1922 publications were identified, of which twenty-four articles were included in this review. The main drought-related health effects that emerged were divided into 4 main categories: (1) drought and nutritional health including malnutrition, poor childhood health outcomes (wasting, stunting and underweight), mortality, anaemia, and nutritionrelated disability; (2) drought and food consumption including micronutrient deficiencies and motor neuron diseases; (3) drought and water-borne, water-washed and water- related diseases including cholera outbreaks, diarrhoeal diseases, protozoa parasite transmission, scabies outbreaks, trachoma, vector-borne disease outbreaks and malaria-related mortality; and (4) drought and health behaviours including health perceptions and health-seeking behaviours, HIV prevention and care behaviours and family planning practices. There was generally limited evidence in all health categories with several limitations. These limitations include studies with methodological weaknesses (e.g. a lack of comparison to a non-drought period), the singularity of published studies on health effects associated with drought and studies which did not account for potential confounders. While the evidence from the included studies is limited, this study highlights gaps in literature to encourage further research into understanding the direct and indirect impacts of drought on health, particularly in vulnerable groups. Furthermore, the results of this study emphasized the contextual factors which lower an individual's adaptive capacity and identified key indicators that can be used to begin to develop a broad framework for a vulnerability index