Browsing by Subject "Antimalarial Drug"

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    Impactful maps and associated visualisations on antimalarial drug resistance for malaria programmes and policymakers
    (2025) Kagoro, Frank; Barnes, Karen
    The spread of antimalarial drug resistance threatens global, regional and national malaria elimination efforts. Despite being preventable and treatable, malaria still claims over half a million lives globally, with over 95% of malaria cases and deaths occurring in Africa. Antimalarial drug resistance threatens progress in malaria control and elimination, especially in less-resourced health systems in developing countries. Malaria control and elimination efforts are facing stagnation of funding and competing resources with other potential pandemic pathogens like COVID-19, HIV, tuberculosis and non-communicable diseases. Regrettably, the malaria programmes and policymakers who are at the forefront of confronting antimalarial drug resistance often lack timely monitoring tools for evidence-based decision-making. This thesis used an iterative, sequential, explanatory, mixed-methods design to strengthen evidence on Plasmodium falciparum antimalarial drug resistance in Asia and South Africa. Through four thesis chapters of peer-reviewed manuscripts, the thesis presents innovative approaches to developing impactful policymaker-friendly tools for detection, reporting and responding to antimalarial drug resistance. Through co-design techniques, the thesis addresses major data challenges and developed guidelines and tools to support near-real-time antimalarial resistance monitoring. The thesis also highlights important processes and pinch points in rolling out an early warning system for antimalarial drug resistance in a pre- elimination setting in South Africa. This research contributes to best practices in summarising evidence for antimalarial drug resistance for policymakers and decision-makers. Furthermore, this thesis provides insights on the process of establishing an early warning system in a pre-elimination malaria setting, a context reflective of where several Southern African countries and Island states are heading in this decade.