Browsing by Author "Saunders, Colleen Jayne"

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    Extracellular matrix gene sequence variant analyses and Achilles tendinopathy
    (2013) Saunders, Colleen Jayne; September, Alison; Schwellnus, Martin; Collins, Malcolm
    The primary aim of this thesis was to identify additional genetic elements predisposing individuals to risk of AT using a candidate gene, case-control genetic association approach, and to propose the biological mechanisms underlying this genetic risk. Candidate genes (COMP, THBS2, COL27A1, TNC, COL3A1, COL5A2 and COL5A3) were selected based on their chromosomal location and/or the biological function of their encoded proteins within the extracellular matrix (ECM) of the tendon.