Browsing by Author "Roederer, M"

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    Increased differentiation associates with decreased polyfunctionality for HIV but not CMV-specific CD8+ T cell responses
    (BioMed Central Ltd, 2012) Riou, C; Abrahams, M; Mlisana, K; Koup, R; Roederer, M; Karim, S; de Bruyn, G; Williamson, C; Gray, CM; Burgers, WA
    The generation of polyfunctional CD8+ T cells, in response to vaccination or natural infection, has been associated with improved protective immunity. However, it remains unclear whether the maintenance of polyfunctionality is linked to particular phenotypic characteristics of the cell, such as the differentiation stage of memory T cells. The goal of this study was to investigate the relationship between the memory maturation stage and polyfunctional profiles of antigen-specific CD8+ T cells.