Browsing by Author "Petro, Greg"

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    The association between timing of initiation of antenatal care and stillbirths: a retrospective cohort study of pregnant women in Cape Town, South Africa
    (BioMed Central, 2014-06-13) Beauclair, Roxanne; Petro, Greg; Myer, Landon
    Background: There is renewed interest in stillbirth prevention for lower-middle income countries. Early initiation of and properly timed antenatal care (ANC) is thought to reduce the risk of many adverse birth outcomes. To this end we examined if timing of the first ANC visit influences the risk of stillbirth. Methods: We conducted an analysis of a retrospective cohort of women (n = 34,671) with singleton births in a public perinatal service in Cape Town, South Africa. The main exposure was the gestational age at the first ANC visit. Bivariable analyses examining maternal characteristics by stillbirth status and gestational age at the first ANC visit, were conducted. Logistic regression, adjusting for maternal characteristics, was conducted to determine the risk of stillbirth. Results: Of the 34,671 women who initiated ANC, 27,713 women (80%) were retained until delivery. The population stillbirth rate was 4.3 per 1000 births. The adjusted models indicated there was no effect of gestational age at first ANC visit on stillbirth outcomes when analyzed as a continuous variable (aOR 1.01; 95% CI: 0.99-1.04) or in trimesters (2nd Trimester aOR 0.78, 95% CI: 0.39-1.59; 3rd Trimester OR 1.03, 95% CI: 0.50-2.13, both with 1st Trimester as reference category). The findings were unchanged in sensitivity analyses of unobserved outcomes in non-retained women. Conclusion: The timing of a woman’s first ANC visit may not be an important determinant of stillbirths in isolation. Further research is required to examine how quality of care, incorporating established, effective biomedical interventions, influences outcomes in this setting.
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    Cohort Profile: The Western Cape Pregnancy Exposure Registry (WCPER)
    (2022-06) Kalk, Emma; Heekes, Alexa; Slogrove, Amy; Phelanyane, Florence; Davies, Mary-Ann; Myer, Landon; Euvrard, Jonathan; Kroon, Max; Petro, Greg; Fieggen, Karen; Stewart, Chantal; Rhoda, Natasha; Gebhardt, Stefan; Osman, Ayesha; Anderson, Kim; Boulle, Andrew; Mehta, Ushma
    Purpose: The Western Cape Pregnancy Exposure Registry (PER) was established at two public sector healthcare sentinel sites in the Western Cape province, South Africa, to provide ongoing surveillance of drug exposures in pregnancy and associations with pregnancy outcomes. Participants: Established in 2016, all women attending their first antenatal visit at primary care obstetric facilities were enrolled and followed to pregnancy outcome regardless of the site (ie, primary, secondary, tertiary facility). Routine operational obstetric and medical data are digitised from the clinical stationery at the healthcare facilities. Data collection has been integrated into existing services and information platforms and supports routine operations. The PER is situated within the Provincial Health Data Centre, an information exchange that harmonises and consolidates all health-related electronic data in the province. Data are contributed via linkage across a unique identifier. This relationship limits the missing data in the PER, allows validation and avoids misclassification in the population-level data set. Findings to date: Approximately 5000 and 3500 pregnant women enter the data set annually at the urban and rural sites, respectively. As of August 2021, >30 000 pregnancies have been recorded and outcomes have been determined for 93%. Analysis of key obstetric and neonatal health indicators derived from the PER are consistent with the aggregate data in the District Health Information System. Future plans: This represents significant infrastructure, able to address clinical and epidemiological concerns in a low/middle-income setting.
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    Pregnancy intendedness in a high-risk obstetric population in a regional hospital
    (2024) Akpakan, Akanimo; Van Der Spuy, Zephne; Kadwa, Khatija; Petro, Greg; Firmin, Carl
    Unintended pregnancies (UIP) are those that are mistimed, unplanned, or unwanted at the time of conception. It is estimated that, worldwide, 40% of pregnancies were unplanned in 2012 and this carries increased risks for both mothers and babies. This study was designed to utilise the London Measure of Unplanned Pregnancy (LMUP) to assess pregnancy intendedness in a high-risk obstetric population of women who were accessing care at a large regional hospital. Methods: This was a cross-sectional descriptive study. Women attending the High-Risk clinics or admitted with medical problems were recruited at George Regional Hospital. Once they consented to the study, the LMUP was administered by a single research team member. The LMUP is a psychometrically validated measure of pregnancy intention for a current or recent pregnancy. Questions enquire about the intention and timing of pregnancy, preconception behaviour, contraception usage, and partner's input and a score is obtained which indicates intendedness. It has been validated in our department in the 3 local languages. Results: A total of 200 women were recruited for the study. No potential participant declined to be interviewed. The mean age was 30.4+/- 6.3 years and the majority of participants were of mixed ancestry (n=135). HIV status was positive for 23 participants and unknown for 29. All participants completed the Perinatal Mental Health Score and 4 required referrals for supportive assistance. The LMUP indicated that 76 women had unintended pregnancies, 58 were ambivalent about their pregnancies and 66 had an intended pregnancy. Pre-pregnancy discussion and preparation were lacking for most of the participants despite pre-existing risk factors. Pregnancy intendedness was affected by several factors. Age (P = 0.02), relationship status (P = 0.001) and financial support (P = 0.005) were associated with intendedness. Employment, parity, language group, educational level, booking gestation, HIV status, and multiple comorbidities did not affect pregnancy intendedness. Other factors that had no influence were Perinatal Mental Health Score, preconceptual counselling/health improvement, and habits. Poor partner communication was common. Women at extremes of reproductive life had more unplanned pregnancies (P = 0.02). i There was good unprompted contraceptive knowledge but poor information about emergency contraception. Conclusion: In this high-risk group of obstetric patients, there was little preconception discussion or preparation and inadequate use of contraception among women who did not plan a pregnancy.
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    Self-reported side effects and adherence to antiretroviral therapy in HIV-infected pregnant women under option B+: a prospective study
    (Public Library of Science, 2016) Phillips, Tamsin; Cois, Annibale; Remien, Robert H; Mellins, Claude A; McIntyre, James A; Petro, Greg; Abrams, Elaine J; Myer, Landon
    BACKGROUND: Antiretroviral therapy (ART) regimens containing efavirenz (EFV) are recommended as part of universal ART for pregnant and breastfeeding women. EFV may have appreciable side effects (SE), and ART adherence in pregnancy is a major concern, but little is known about ART SE and associations with adherence in pregnancy. METHODS: We investigated the distribution of patient-reported SE (based on Division of AIDS categories) and the association of SE with missed ART doses in a cohort of 517 women starting EFV+3TC/FTC+TDF during pregnancy. In analysis, SE were considered in terms of their overall frequency, by systems category, and by latent classes. RESULTS: Overall 97% of women reported experiencing at least one SE after ART initiation, with 48% experiencing more than five SE. Gastrointestinal, central nervous system, systemic and skin SE were reported by 81%, 85%, 79% and 31% of women, respectively, with considerable overlap across groups. At least one missed dose was reported by 32% of women. In multivariable models, ART non-adherence was associated with systemic SE compared to other systems categories, and measures of the overall burden of SE experienced were most strongly associated with missed ART doses. CONCLUSION: These data demonstrate very high levels of SE in pregnant women initiating EFV-based ART and a strong association between SE burden and ART adherence. ART regimens with reduced SE profiles may enhance adherence, and as countries expand universal ART for all adult patients, counseling must include preparation for ART SE.