Browsing by Author "Mabotha, Tebogo E"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
- ItemOpen AccessThe application of physicochemical methods for the analysis of small and complex pharmaceutical drugs(2003) Mabotha, Tebogo E; Ravenscroft, Neil; Jackson, Graham EllisThe application of physicochemical methods for the analysis of small and complex pharmaceutical drugs was investigated. The methods were applied to small chiral molecules and further extended to analysis of complex glycoconjugate vaccines.
- ItemOpen AccessHaemozoin formation, effects of chloroquine on iron distribution in Plasmodium falciparum and the correlation of thermordynamic and structural factors with 4-aminoquinoline activity(2007) Mabotha, Tebogo EAn interfacial method was developed in order to investigate the role lipids might play in haemozoin biosynthesis. Infrared and X-ray diffraction measurements demonstrated that β-haematin, a synthetic counterpart of haemozoin, forms efficiently at pentanol/water, octanol/water and lipid/water interfaces, but to a lesser extent at toluene/water interface under physiological conditions of pH and temperature and does not form at all in the absence of the interface.