Browsing by Author "Hamdi, Yosr"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Open Access
    African Genomic Medicine Portal: A Web Portal for Biomedical Applications
    (2022-02-11) Othman, Houcemeddine; Zass, Lyndon; da Rocha, Jorge E B; Radouani, Fouzia; Samtal, Chaimae; Benamri, Ichrak; Kumuthini, Judit; Fakim, Yasmina J; Hamdi, Yosr; Mezzi, Nessrine; Boujemaa, Maroua; Okeke, Chiamaka Jessica; Tendwa, Maureen B; Sanak, Kholoud; Chaouch, Melek; Panji, Sumir; Kefi, Rym; Sallam, Reem M; Ghoorah, Anisah W; Romdhane, Lilia; Kiran, Anmol; Meintjes, Ayton P; Maturure, Perceval; Jmel, Haifa; Ksouri, Ayoub; Azzouzi, Maryame; Farahat, Mohammed A; Ahmed, Samah; Sibira, Rania; Turkson, Michael E E; Ssekagiri, Alfred; Parker, Ziyaad; Fadlelmola, Faisal M; Ghedira, Kais; Mulder, Nicola; Kamal Kassim, Samar
    Genomics data are currently being produced at unprecedented rates, resulting in increased knowledge discovery and submission to public data repositories. Despite these advances, genomic information on African-ancestry populations remains significantly low compared with European- and Asian-ancestry populations. This information is typically segmented across several different biomedical data repositories, which often lack sufficient fine-grained structure and annotation to account for the diversity of African populations, leading to many challenges related to the retrieval, representation and findability of such information. To overcome these challenges, we developed the African Genomic Medicine Portal (AGMP), a database that contains metadata on genomic medicine studies conducted on African-ancestry populations. The metadata is curated from two public databases related to genomic medicine, PharmGKB and DisGeNET. The metadata retrieved from these source databases were limited to genomic variants that were associated with disease aetiology or treatment in the context of African-ancestry populations. Over 2000 variants relevant to populations of African ancestry were retrieved. Subsequently, domain experts curated and annotated additional information associated with the studies that reported the variants, including geographical origin, ethnolinguistic group, level of association significance and other relevant study information, such as study design and sample size, where available. The AGMP functions as a dedicated resource through which to access African-specific information on genomics as applied to health research, through querying variants, genes, diseases and drugs. The portal and its corresponding technical documentation, implementation code and content are publicly available.
  • No Thumbnail Available
    Item
    Open Access
    Fighting Cancer around the World: A Framework for Action
    (2022-10-25) Horgan, Denis; Mia, Rizwana; Erhabor, Tosan; Hamdi, Yosr; Dandara, Collet; Lal, Jonathan A.; Domgue, Joel Fokom; Ewumi, Oladimeji; Nyawira, Teresia; Meyer, Salomé; Kondji, Dominique; Francisco, Ngiambudulu M.; Ikeda, Sadakatsu; Chuah, Chai; De Guzman, Roselle; Paul, Anupriya; Reddy Nallamalla, Krishna; Park, Woong-Yang; Tripathi, Vijay; Tripathi, Ravikant; Johns, Amber; Singh, Mohan P.; Phipps, Maude E.; Dube, France; Whittaker, Kate; Mukherji, Deborah; Rasheed, Hadi Mohamad Abu; Kozaric, Marta; Pinto, Joseph A.; Doral Stefani, Stephen; Augustovski, Federico; Aponte Rueda, Maria Eugenia; Fujita Alarcon, Ricardo; Barrera-Saldana, Hugo A.
    Tackling cancer is a major challenge right on the global level. Europe is only the tip of an iceberg of cancer around the world. Prosperous developed countries share the same problems besetting Europe–and the countries and regions with fewer resources and less propitious conditions are in many cases struggling often heroically against a growing tide of disease. This paper offers a view on these geographically wider, but essentially similar, challenges, and on the prospects for and barriers to better results in this ceaseless battle. A series of panels have been organized by the European Alliance for Personalised Medicine (EAPM) to identify different aspects of cancer care around the globe. There is significant diversity in key issues such as NGS, RWE, molecular diagnostics, and reimbursement in different regions. In all, it leads to disparities in access and diagnostics, patients’ engagement, and efforts for a better understanding of cancer.