Browsing by Author "Dabee, S"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Open Access
    Impact of the innate environment on maintaining memory T-cell numbers in the female genital tract: implications for mucosal vaccine efficacy?
    (BioMed Central Ltd, 2012) Dabee, S; Passmore, J; Williamson, A; Gumbi, P
    Preventative HIV vaccines aim to elicit long-lived protective immune responses at the site of HIV transmission, capable of responding quickly to HIV challenge, but which remain stable at effector sites of the genital mucosa. The genital mucosa is, however, commonly confronted with innate immune modifiers and inflammatory agents including sexually-transmitted infections, behavioural and hygiene practices. We investigated the impact of mucosal inflammation and homeostatic cytokines on local T-cell phenotype, proliferation, exhaustion and activation.