Browsing by Author "Cashmore, Tamaryn Jane"

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    Utility of newer technologies for the diagnosis of active and latent tuberculosis
    (2010) Cashmore, Tamaryn Jane; Dheda, Keertan
    Since the 1800s the tuberculin skin test (TST) has been the only available test for latent tuberculosis (LTBI). Recently, interferon-gamma release assays (IGRAs) have been developed which are based upon the responses of peripheral blood effector cells to M.tb-specific antigens [early secretory antigenic target -6 (ESAT-6) and culture filtrate protein (CFP10)]. Discordance between the TST and IGRAs has been well documented but remains largely unexplained.