Browsing by Author "Brink, Johan"

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    The initiative to investigate the management of Pericarditis in Africa (IMPI) Registry : a substudy on the causes of constrictive pericarditis and predictors of mortality in patients with constrictive pericarditis requiring pericardiectomy at Groote Schuur Hospital (The Constrictive Pericarditis Substudy)
    (2015) Mutyaba, Arthur Kaggwe; Mayosi, Bongani M; Brink, Johan
    Background: Causes of constrictive pericarditis and predictors of peri-operative outcome following pericardiectomy are not clearly elucidated, especially in Africa, where disease characteristics differ from developed countries. Furthermore, the impact of HIV/AIDS on pericardial constriction and outcomes following surgery is unknown. We set out to investigate the causes of constrictive pericarditis, the outcomes after pericardiectomy and the predictors of mortality in Cape Town, South Africa during a 22-year period of high HIV/AIDS prevalence. Methods: A retrospective review of records of all patients who underwent pericardiectomy for constrictive pericarditis at Groote Schuur Hospital from 1 January 1990 to 31 December 2012 was performed.
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    Medicine and the Arts Week 1 - In dialogue about the heart
    (2015-01-21) Reid, Steve; Brink, Johan; Anderson, Peter; Henkeman, Stanley
    In this video, Professor Steve Reid poses additional questions to Professor Johan Brink, poet Peter Anderson, and heart transplant recipient Stanley Henkeman to try to tease out the different disciplinary perspectives on the heart and heart transplantation. This is the seventh video in Week 1 of the Medicine and the Arts Massive Open Online Course.
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    Medicine and the Arts Week 1 - On heart transplants
    (2015-01-21) Brink, Johan
    In this video, Johan Brink, discusses how his perspective on heart transplantation is informed by his experience as a cardiac surgeon. He emphasises the centrality of the heart for being human: physically, as an organ which keeps our bodies alive and emotionally, as a symbol of our feelings of love. He also notes that that a heart transplant is a complex medical procedure that raises a number of ethical questions. This is the fourth video in Week 1 of the Medicine and the Arts Massive Open Online Course.
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    Medicine and the Arts Week 1 - The Heart of the Matter
    (2015-01-21) Reid, Steve; Brink, Johan
    In this video, Professor Steve Reid describes how the course will use the extraordinary medical intervention of the heart transplant as a means of understanding the interdisciplinarary nature of the medical humanities. He explains how the heart transplant will be presented from three different perspectives: Professor Johan Brink, a cardiac surgeon, will discuss the medical aspects of the heart transplant, such as the surgery itself and the risks and benefits of the procedure. Peter Andersen, a poet, will discuss the heart from a literary perspective, in terms of metaphor and symbolism. And Stan Henkeman, a heart transplant recipient, will share his personal story of hope and renewal. This is the third video in Week 1 of the Medicine and the Arts Massive Open Online Course.
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    PROSE: Prospective Randomized Trial of the On-X Mechanical Prosthesis and the St Jude Medical Mechanical Prosthesis Evaluation
    (2021-11-03) Jamieson, W R E; Ely, John L; Brink, Johan; Pennel, Timothy; Bannon, Paul; Patel, Jashvant; Kumar Gupta, Rajiv; Mohan Rao, Prasanna S; Agrawal, Damyanti; Wiklund, Lars; Kappetein, A P; Haaverstad, Rune; Geisner, Thomas; Doenst, Torsten; Schlensak, Christian; Nair, Salgunan; Brown, Craig; Siepe, Matthias; Damiano, Ralph J; Langlois, Yves; Cherian, K M; Azar, Hormoz; Chen, John C; Bavaria, Joseph E; Fedoruk, Lynn M; Munfakh, Nabil A; Sridhar, V; Scholz, Peter M; Pfeffer, Thomas A; Ye, Jian
    Objectives The PROSE trial purpose is to investigate whether the incidence of thromboembolic—related complications is reduced with a current generation mechanical prosthesis (On-X Life Technologies/CryoLife Inc.—On-X) compared with a previous generation mechanical prosthesis (St Jude Medical—SJM). The primary purpose of the initial report is to document the preoperative demographics, and the preoperative and operative risk factors by individual prosthesis and by Western and Developing populations. Methods The PROSE study was conducted in 28 worldwide centres and incorporated 855 subjects randomized between 2003 and 2016. The study enrollment was discontinued on August 31, 2016. The preoperative demographics incorporated age, gender, functional class, etiology, prosthetic degeneration, primary rhythm, primary valve lesion, weight, height, BSA and BMI. The preoperative and operative evaluation incorporated 24 risk factors. Results The total patient population (855) incorporated On-X population (462) and the St Jude Medical population (393). There was no significant difference of any of the preoperative demographics between the On-X and SJM groups. The preoperative and operative risk factors evaluation showed there was no significant difference between the On-X and St Jude Medical populations. The preoperative and operative risk factors by valve position (aortic and mitral) also documented no differentiation. The dominant preoperative demographics of the Western world population were older age, male gender, sinus rhythm, aortic stenosis, congenital aortic lesion, and mitral regurgitation. The dominant demographics of the Developing world population were rheumatic etiology, atrial fibrillation, aortic regurgitation, mixed aortic lesions, mitral stenosis and mixed mitral lesions. The Developing world group had only one significant risk factor, congestive heart failure. The majority of the preoperative and operative risk factors were significant in the Western world population. Conclusions The preoperative demographics do not differentiate the prostheses but do differentiate the Western and Developing world populations. The preoperative and operative risk factors do not differentiate the prostheses BUT do differentiate the Western and Developing world populations.
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    Pulmonary aspergillomata: an assessment of clinical outcome after surgical resection and of the most immune response to aspergillus infection at cellular level
    (2006) Lichtenberg, Wilhelm S A; Walther, Gabi; Brink, Johan
    A pulmonary aspergilloma, one of the forms of pulmonary disease caused by the ubiquitous fungus Aspergil/us species, is a secondary fungal infection imposed on pre-existing pulmonary disease. It is commonly associated with haemoptysis, which may be life-threatening 8•9•12•17- 19 •30. Colonisation of pre-existing cavities due to previous infection with mycobacterium tuberculosis is well described 1•2. In South Africa, due to the high incidence of pulmonary tuberculosis 73, pulmonary aspergillomata are frequently encountered.