Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles

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dc.contributor.advisorTanzer, Fionaen_ZA
dc.contributor.advisorJaffray, Annen_ZA
dc.contributor.advisorRybicki, Eden_ZA
dc.contributor.authorHalsey, Richard Jamesen_ZA
dc.date.accessioned2014-07-30T17:38:22Z
dc.date.available2014-07-30T17:38:22Z
dc.date.issued2006en_ZA
dc.descriptionIncludes bibliographical references (leaves 114-128).
dc.description.abstractIn this study I explored the possibility of making HIV-1 subtype C Pr55gag-based chimaeric virus-like particles (VLPs) as a boost to the HIV-IC multigene DNA vaccine pTHr.grttnC, which encodes a modified Gag-RT-Tat-Nef fusion protein (GRTTN). Furthermore, an attempt was made to produce VLP analogues to the HIV-IA polyepitope DNA vaccine pTHr.HIVA. A range of in-frame fusions with the C-termini of myristylation-competent p6-truncated Gag and native Pr55gag were made to test how the length of polypeptide and its sequence might affect VLP formation and structure.en_ZA
dc.identifier.apacitationHalsey, R. J. (2006). <i>Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/4269en_ZA
dc.identifier.chicagocitationHalsey, Richard James. <i>"Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2006. http://hdl.handle.net/11427/4269en_ZA
dc.identifier.citationHalsey, R. 2006. Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Halsey, Richard James AB - In this study I explored the possibility of making HIV-1 subtype C Pr55gag-based chimaeric virus-like particles (VLPs) as a boost to the HIV-IC multigene DNA vaccine pTHr.grttnC, which encodes a modified Gag-RT-Tat-Nef fusion protein (GRTTN). Furthermore, an attempt was made to produce VLP analogues to the HIV-IA polyepitope DNA vaccine pTHr.HIVA. A range of in-frame fusions with the C-termini of myristylation-competent p6-truncated Gag and native Pr55gag were made to test how the length of polypeptide and its sequence might affect VLP formation and structure. DA - 2006 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles TI - Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles UR - http://hdl.handle.net/11427/4269 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/4269
dc.identifier.vancouvercitationHalsey RJ. Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2006 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/4269en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherCell Biologyen_ZA
dc.titleConstruction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particlesen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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