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Browsing by Author "Rybicki, Edward P"

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A deletion and point mutation study of the human papillomavirus type 16 major capsid gene

Author: Varsani, Arvind ; Williamson, Anna-Lise ; Jaffer, Mohamed A ; Rybicki, Edward P Date: 2006 Recombinant human papillomavirus (HPV) virus-like particles (VLPs) made from the major capsid protein L1 are promising vaccine candidates for use as vaccines against genital and other HPV infections, and particularly against HPV-16. However, ... Read more
Characterisation of two aphid picorna-like viruses

Author: Williamson, Carolyn Date: 1988 A new aphid virus, aphid lethal paralysis virus (ALPV), was isolated from laboratory-propagated Rhopalosiphum padi aphids co-infected with R. padi virus (RhPV). ALPV and RhPV were separated and ALPV was characterised in detail. Virions are ... Read more
Characterization of a Novel Chimeric Theileria parva p67 Antigen Which Incorporates into Virus-like Particles and Is Highly Immunogenic in Mice

Author: Whittle, Leah ; Chapman, Ros ; van Diepen, Michiel ; Rybicki, Edward P ; Williamson, Anna-Lise Date: 28 Jan 2022 The current method to protect cattle against East Coast Fever (ECF) involves the use of live <i>Theileria parva</i> sporozoites. Although this provides immunity, using live parasites has many disadvantages, such as contributing to the spread ... Read more c b
Chimaeric HIV-1 subtype C Gag molecules with large in-frame C-terminal polypeptide fusions form virus-like particles.

Author: Halsey, Richard J ; Tanzer, Fiona L ; Meyers, Ann ; Pillay, Sirika ; Lynch, Alisson ; Shephard, Enid ; Williamson, Anna-Lise ; Rybicki, Edward P Date: 2008 HIV-1 Pr55 Gag virus-like particles (VLPs) are strong immunogens with potential as candidate HIV vaccines. VLP immunogenicity can be broadened by making chimaeric Gag molecules: however, VLPs incorporating polypeptides longer than 200 aa fused ... Read more
Design and production of a candidate universal influenza A vaccine in Nicotiana benthamiana plants

Author: De Figueiredo Pinto Gomes Pera, Francisco Date: 2017 The influenza A virus is responsible for 250,000 to 500,000 deaths every year worldwide and millions more could die in the event of a serious pandemic. Vaccines against influenza have existed for long, but until today they have been limited ... Read more
Development of a potential challenge model and plant-produced vaccine candidate for beak and feather disease virus

Author: Regnard, Guy Louis Date: 2015 Psittacine beak and feather disease (PBFD), the most prevalent viral disease affecting psittacines, is caused by beak and feather disease virus (BFDV). An outbreak of the disease has been reported in wild endangered Cape parrots (Poicephalus ... Read more
Development of plant-produced Bluetongue virus vaccines

Author: van Zyl, Albertha R Date: 2014 Bluetongue is a disease of domestic and wild ruminants caused by Bluetongue virus (BTV). It has caused several serious outbreaks, the most recent occurring in Northern Europe in 2006 during which high mortality rates of livestock were reported. ... Read more
Development of plant-produced protein body vaccine candidates for bluetongue virus

Author: van Zyl, Albertha R ; Meyers, Ann E ; Rybicki, Edward P Date: 30 May 2017 Background: Bluetongue is a disease of domestic and wild ruminants caused by bluetongue virus serotypes (BTV), which have caused serious outbreaks worldwide. Commercially available vaccines are live-attenuated or inactivated virus strains: ... Read more
Development of Rift Valley fever virus candidate vaccines and reagents produced in Nicotiana benthamiana

Author: Mbewana, Sandiswa Date: 2017 Rift Valley fever (RVF) is a haemorrhagic fever agent caused by an infection with an enveloped negative-stranded RNA Rift Valley fever virus (RVFV). It belongs to the genus Phlebovirus in the family Bunyaviridae. The virus is spread by infected ... Read more
The development of transgenic plants resistant to cucumber mosaic virus and tobacco necrosis virus

Author: Hackland, Andrew F Date: 1994 Cucumber mosaic virus (CMV) and tobacco necrosis virus (TN V) often occur in mixed virus infections in South Africa. Both viruses are of economic importance because of their world-wide distribution, extensive host range and their effects on ... Read more
Evidence of ancient papillomavirus recombination

Author: Varsani, Arvind ; van der Walt, Eric ; Heath, Livio ; Rybicki, Edward P ; Williamson, Anna Lise ; Martin, Darren P Date: 2006 An open question amongst papillomavirus taxonomists is whether recombination has featured in the evolutionary history of these viruses. Since the onset of the global AIDS epidemic, the question is somewhat less academic, because immune-compromised ... Read more
The Evolutionary Value of Recombination Is Constrained by Genome Modularity

Author: Martin, Darren P ; Walt, Eric van der ; Posada, David ; Rybicki, Edward P Date: 2005 Genetic recombination is a fundamental evolutionary mechanism promoting biological adaptation. Using engineered recombinants of the small single-stranded DNA plant virus, Maize streak virus (MSV), we experimentally demonstrate that fragments ... Read more c b
Experimental observations of rapid Maize streak virus evolution reveal a strand-specific nucleotide substitution bias

Author: van der Walt, Eric ; Martin, Darren P A ; Varsani, Arvind ; Polston, Jane E ; Rybicki, Edward P Date: 2008 Background: Recent reports have indicated that single-stranded DNA (ssDNA) viruses in the taxonomic families Geminiviridae, Parvoviridae and Anellovirus may be evolving at rates of ~10-4 substitutions per site per year (subs/site/year). These ... Read more c b
Expression optimization of a human papillomavirus type 16 therapeutic vaccine candidate in Nicotiana benthamiana leaves

Author: Do Rosario Yanez, Romana de Jesus Date: 2016 High risk human papillomaviruses (HPVs) are the causative agents of cervical cancer. The three approved prophylactic vaccines do not benefit already infected individuals; therefore, there is still an urgent need for therapeutic vaccines. The ... Read more
Genetic analysis of maize streak virus isolates from Uganda reveals widespread distribution of a recombinant variant.

Author: Owor, Betty E ; Martin, Darren P ; Shepherd, Dionne N ; Edema, Richard ; Monjane, Ade´rito L ; Rybicki, Edward P ; Thomson, Jennifer A ; Vasani, Arvind Date: 2007 Maize streak virus (MSV) contributes significantly to the problem of extremely low African maize yields. Whilst a diverse range of MSV and MSV-like viruses are endemic in sub-Saharan Africa and neighbouring islands, only a single group of ... Read more
A highly divergent South African geminivirus species illuminates the ancient evolutionary history of this family

Author: Varsani, Arvind ; Shepherd, Dionne N ; Dent, Kyle ; Monjane, Aderito L ; Rybicki, Edward P ; Martin, Darren P Date: 2009 Background: We have characterised a new highly divergent geminivirus species, Eragrostis curvula streak virus (ECSV), found infecting a hardy perennial South African wild grass. ECSV represents a new genus-level geminivirus lineage, and has ... Read more c b
HIV-1 sub-type C chimaeric VLPs boost cellular immune responses in mice

Author: Pillay, Sirika ; Shephard, Enid ; Meyers, Ann ; Williamson, Anna-Lise ; Rybicki, Edward P Date: 2010 Several approaches have been explored to eradicate HIV; however, a multigene vaccine appears to be the best option, given their proven potential to elicit broad, effective responses in animal models. The Pr55Gag protein is an excellent vaccine ... Read more c b
Identification of two potyviruses of phaseolus vulgaris in South Africa

Author: Van Tonder, Tertia Date: 1997 A survey was conducted by researchers at ARC-PPRI on dry beans (Phaseolus vulgaris) during 1993. All the viruses known to occur on dry beans in South Africa were found, as well as a few unidentified viruses. Of these, samples 93/1 and 93/65 ... Read more
Immunogenic assessment of plant-produced Human papillomavirus type 16 chimaeric L1:L2 virus-like particles and the production of an encapsidated therapeutic DNA vaccine candidate

Author: Chabeda, Eva Aleyo Date: 2017 Cervical cancer caused by infection with Human papillomavirus (HPV) is the 4th most common cancer in women globally, and results in an estimated 266 000 deaths every year. Current vaccines are based on the immunodominant L1 major capsid ... Read more
An investigation into the high level production of proteins in tobacco using transgenic plants or viral vectors

Author: Gehringer, Michelle Martine Date: 1996 The aim of this project was to construct a high level plant expression vector from the RNA 3 of cucumber mosaic virus strain Y (CMV Y). The 5'- and 3'-untranslated regions (UTRs) of this genome segment were reverse transcribed, cloned and ... Read more

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