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Browsing by Author "Hussey, Gregory"

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Advances in childhood immunisation in South Africa: where to now? Programme managers' views and evidence from systematic reviews

Author: Wiysonge, Charles ; Ngcobo, Nthombenhle ; Jeena, Prakash ; Madhi, Shabir ; Schoub, Barry ; Hawkridge, Anthony ; Shey, Muki ; Hussey, Gregory Date: 2012 BACKGROUND: The Expanded Programme on Immunisation (EPI) is one of the most powerful and cost-effective public health programmes to improve child survival. We assessed challenges and enablers for the programme in South Africa, as we approach ... Read more c b
Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants

Author: Randhawa, April Kaur ; Shey, Muki S ; Keyser, Alana ; Peixoto, Blas ; Wells, Richard D ; de Kock, Marwou ; Lerumo, Lesedi ; Hughes, Jane ; Hussey, Gregory ; Hawkridge, Anthony ; Kaplan, Gilla ; Hanekom, Willem A ; Hawn, Thomas R Date: 2011 The development of effective immunoprophylaxis against tuberculosis (TB) remains a global priority, but is hampered by a partially protective Bacillus Calmette-Guérin (BCG) vaccine and an incomplete understanding of the mechanisms of immunity ... Read more c b
Comparison of mantoux and tine tuberculin skin tests in BCG-vaccinated children investigated for tuberculosis

Author: Pan, Wenli ; Matizirofa, Lyness ; Workman, Lesley ; Hawkridge, Tony ; Hanekom, Willem ; Mahomed, Hassan ; Hussey, Gregory ; Hatherill, Mark Date: 2009 Background: Tuberculin skin tests (TSTs) are long-established screening methods for tuberculosis (TB). We aimed to compare agreement between the intradermal Mantoux and multipuncture percutaneous Tine methods and to quantify risk factors for ... Read more c b
Culture-confirmed childhood tuberculosis in Cape Town, South Africa: a review of 596 cases

Author: Schaaf, H Simon ; Marais, Ben ; Whitelaw, Andrew ; Hesseling, Anneke ; Eley, Brian ; Hussey, Gregory ; Donald, Peter Date: 2007 BACKGROUND:The clinical, radiological and microbiological features of culture-confirmed childhood tuberculosis diagnosed at two referral hospitals are described. METHODS: Cultures of Mycobacterium tuberculosis from children less than 13 years ... Read more c b
Epidemiology of pertussis in children hospitalised with respiratory tract infection

Author: Muloiwa, Rudzani Date: 2021 The availability of an effective vaccine against Bordetella pertussis substantially reduced the morbidity and mortality from pertussis, however, in the last decade there appears to have been a substantial increase in pertussis cases as reported ... Read more
The incidence of tuberculosis in adolescents in the context of proposed TB vaccine trials

Author: Mahomed, Hassan Date: 2013 [Background] Tuberculosis (TB) is a significant global health problem and the development of new TB vaccines is one strategy proposed to address this scourge. Adolescents are a potential target group for new TB vaccines. Limited data are ... Read more
Initial experience of a public sector antiretroviral treatment programme for HIV-infected children and their infected parents

Author: Eley, Brian ; Nuttall, James ; Davies, Mary-Ann ; Smith, Lara ; Cowburn, Carol ; Buys, Heloise ; Hussey, Gregory Date: 2004 Objective. To describe the initial experience of treating HIVinfected children and their infected parents with antiretroviral therapy. Design. Prospective, cohort study. Setting. Tertiary, referral hospital. Patients. HIV-infected children ... Read more
Isolation of Non-Tuberculous Mycobacteria in Children Investigated for Pulmonary Tuberculosis

Author: Hatherill, Mark ; Hawkridge, Tony ; Whitelaw, Andrew ; Tameris, Michele ; Mahomed, Hassan ; Moyo, Sizulu ; Hanekom, Willem ; Hussey, Gregory Date: 2006 Objective To evaluate the frequency and clinical significance of non-tuberculous mycobacteria (NTM) isolates among children investigated for pulmonary tuberculosis in a rural South African community. METHODS: Children were investigated for ... Read more c b
Optimal tuberculosis case-finding methodologies for field trials of new tuberculosis vaccines in young children

Author: Moyo, Sizulu Date: 2013 There is paucity of evidence to guide case-finding strategies in field trials of new tuberculosis vaccines conducted in young children. To investigate case-finding and case detection methods for tuberculosis in tuberculosis field trials ... Read more
Oral trimethoprim-sulphamethoxazole levels in stable HIV-infected children

Author: Zar, Heather J ; Langdon, Grant ; Apolles, Patti ; Eley, Brian ; Hussey, Gregory ; Smith, Peter Date: 2006 Background. Effective treatment of Pneumocystis jiroveci pneumonia (PCP) requires therapeutic serum concentrations of 5 - 10 µg/ml trimethoprim (TMP); consequently intravenous trimethoprim-sulphamethoxazole (TMP-SMZ) is recommended therapy. ... Read more
Pneumonia in HIV-infected children admitted to hospital in Cape Town, South Africa

Author: Zar, Heather Date: 2000 There is little information on the aetiology and outcome of HIV-associated pneumonia in African children and no comprehensive data from South Africa. Studies of HIV-infected adult in Africa reported that the spectrum of pulmonary disease ... Read more
A quick guide to the clinical care of children infected with HIV

Author: Shung King, Maylene ; Giese, Sonja ; Hussey, Gregory Date: Apr 2002 Read more c b n d
Understanding interventions for improving routine immunization coverage in children in low- and middle-income countries: a systematic review protocol

Author: Machingaidze, Shingai ; Rehfuess, Eva ; von Kries, Rudiger ; Hussey, Gregory ; Wiysonge, Charles Date: 2013 BACKGROUND: Virtually all low- and middle-income countries are dependent on the World Health Organization's Expanded Program on Immunization for delivery of vaccines to children. The Expanded Program on Immunization delivers routine immunization ... Read more c b
Vaginal microbicides for reducing the risk of sexual acquisition of HIV infection in women: systematic review and meta-analysis

Author: Obiero, Jael ; Mwethera, Peter ; Hussey, Gregory ; Wiysonge, Charles Date: 2012 BACKGROUND: Each year more than two million people are newly infected with HIV worldwide, a majority of them through unprotected vaginal sex. More than half of new infections in adults occur in women. Male condoms and male circumcision reduce ... Read more c b
Varicella zoster virus-associated morbidity and mortality in Africa – a systematic review

Author: Hussey, Hannah ; Abdullahi, Leila ; Collins, Jamie ; Muloiwa, Rudzani ; Hussey, Gregory ; Kagina, Benjamin Date: 14 Nov 2017 Background: Varicella zoster virus (VZV) causes varicella and herpes zoster. These vaccine preventable diseases are common globally. Most available data on VZV epidemiology are from industrialised temperate countries and cannot be used to ... Read more

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