Plasma vitamin A and zinc levels in HIV-infected adults in Cape Town, South Africa

Simple item page
dc.contributor.authorVisser, M E
dc.contributor.authorMaartens, G
dc.contributor.authorKossew, G
dc.contributor.authorHussey, G D
dc.date.accessioned2021-10-08T07:08:29Z
dc.date.available2021-10-08T07:08:29Z
dc.date.issued2003
dc.description.abstractA cross-sectional study of 132 adults attending an HIV clinic in Cape Town, South Africa, was conducted to determine predictors of low plasma vitamin A and Zn levels. No patients were on antiretroviral therapy. The possible confounding effect of the acute-phase response was controlled by including C-reactive protein levels in multivariate analysis and by excluding active opportunistic infections. Retinol levels were low (< 1.05 μmol/l) in 39% of patients with early disease (WHO clinical stages I and II) compared with 48 and 79 % of patients with WHO stage III and IV respectively (P<0.01). Plasma Zn levels were low (< 10.7 μmol/l) in 20% of patients with early disease v. 36 and 45 % with stage III and IV disease respectively (P< 0.05). C-reactive protein levels were normal in 63 % of subjects. Weak, positive associations were found between CD4+lymphocyte count and plasma levels of retinol (r 0.27; 95 % CI 0.1, 0.43) and Zn (r 0.31; 95% CI 0.25, 0.46). Multivariate analysis showed the following independent predictors of low retinol levels: WHO stage IV (odds ratio 3.4; 95 % CI 2.1, 5.7) and body weight (odds ratio per 5 kg decrease 1.15; 95% CI, 1-08, 1.25), while only body weight was significantly associated with low Zn levels (OR per 5 kg decrease 1.19; 95% CI 1.09, 1.30). CD4+lymphocyte count <200/μl was not significantly associated with either low retinol or Zn levels. In resource-poor settings, simple clinical features (advanced disease and/or weight loss) are associated with lowered blood concentrations of vitamin A and/or Zn. The clinical significance of low plasma retinol and/or Zn levels is unclear and more research is required to establish the role of multiple micronutrient intervention strategies in HIV disease.
dc.identifier.apacitationVisser, M. E., Maartens, G., Kossew, G., & Hussey, G. D. (2003). Plasma vitamin A and zinc levels in HIV-infected adults in Cape Town, South Africa. <i>Nutrition Research Reviews</i>, 89(4), 475 - 177. http://hdl.handle.net/11427/34591en_ZA
dc.identifier.chicagocitationVisser, M E, G Maartens, G Kossew, and G D Hussey "Plasma vitamin A and zinc levels in HIV-infected adults in Cape Town, South Africa." <i>Nutrition Research Reviews</i> 89, 4. (2003): 475 - 177. http://hdl.handle.net/11427/34591en_ZA
dc.identifier.citationVisser, M.E., Maartens, G., Kossew, G. & Hussey, G.D. 2003. Plasma vitamin A and zinc levels in HIV-infected adults in Cape Town, South Africa. <i>Nutrition Research Reviews.</i> 89(4):475 - 177. http://hdl.handle.net/11427/34591en_ZA
dc.identifier.issn0954-4224
dc.identifier.issn1475-2700
dc.identifier.ris TY - Journal Article AU - Visser, M E AU - Maartens, G AU - Kossew, G AU - Hussey, G D AB - A cross-sectional study of 132 adults attending an HIV clinic in Cape Town, South Africa, was conducted to determine predictors of low plasma vitamin A and Zn levels. No patients were on antiretroviral therapy. The possible confounding effect of the acute-phase response was controlled by including C-reactive protein levels in multivariate analysis and by excluding active opportunistic infections. Retinol levels were low (< 1.05 μmol/l) in 39% of patients with early disease (WHO clinical stages I and II) compared with 48 and 79 % of patients with WHO stage III and IV respectively (P<0.01). Plasma Zn levels were low (< 10.7 μmol/l) in 20% of patients with early disease v. 36 and 45 % with stage III and IV disease respectively (P< 0.05). C-reactive protein levels were normal in 63 % of subjects. Weak, positive associations were found between CD4+lymphocyte count and plasma levels of retinol (r 0.27; 95 % CI 0.1, 0.43) and Zn (r 0.31; 95% CI 0.25, 0.46). Multivariate analysis showed the following independent predictors of low retinol levels: WHO stage IV (odds ratio 3.4; 95 % CI 2.1, 5.7) and body weight (odds ratio per 5 kg decrease 1.15; 95% CI, 1-08, 1.25), while only body weight was significantly associated with low Zn levels (OR per 5 kg decrease 1.19; 95% CI 1.09, 1.30). CD4+lymphocyte count <200/μl was not significantly associated with either low retinol or Zn levels. In resource-poor settings, simple clinical features (advanced disease and/or weight loss) are associated with lowered blood concentrations of vitamin A and/or Zn. The clinical significance of low plasma retinol and/or Zn levels is unclear and more research is required to establish the role of multiple micronutrient intervention strategies in HIV disease. DA - 2003 DB - OpenUCT DP - University of Cape Town IS - 4 J1 - Nutrition Research Reviews LK - https://open.uct.ac.za PY - 2003 SM - 0954-4224 SM - 1475-2700 T1 - Plasma vitamin A and zinc levels in HIV-infected adults in Cape Town, South Africa TI - Plasma vitamin A and zinc levels in HIV-infected adults in Cape Town, South Africa UR - http://hdl.handle.net/11427/34591 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34591
dc.identifier.vancouvercitationVisser ME, Maartens G, Kossew G, Hussey GD. Plasma vitamin A and zinc levels in HIV-infected adults in Cape Town, South Africa. Nutrition Research Reviews. 2003;89(4):475 - 177. http://hdl.handle.net/11427/34591.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Paediatrics and Child Health
dc.publisher.facultyFaculty of Health Sciences
dc.sourceNutrition Research Reviews
dc.source.journalissue4
dc.source.journalvolume89
dc.source.pagination475 - 177
dc.source.urihttps://dx.doi.org/10.1079/BJN2002806
dc.subject.otherHIV infection: Vitamin A: Zinc: C-Reactive Protein: Africa
dc.subject.otherAdult
dc.subject.otherCross sectional study
dc.subject.otherMalnutrition
dc.subject.otherPathophysiology
dc.subject.otherAIDS
dc.subject.otherClinical stage
dc.subject.otherC reactive protein
dc.subject.otherNutrition
dc.subject.otherNutritional status
dc.subject.otherZinc
dc.subject.otherRetinol
dc.subject.otherSouth Africa
dc.subject.otherHuman
dc.subject.otherNutrition disorder
dc.subject.otherImmune deficiency
dc.subject.otherImmunopathology
dc.subject.otherMicronutrient
dc.subject.otherVitamin
dc.subject.otherInfection
dc.subject.otherViral disease
dc.subject.otherAfrica
dc.subject.otherAdulte
dc.subject.otherEtude transversale
dc.subject.otherPhysiopathologie
dc.subject.otherSIDA
dc.titlePlasma vitamin A and zinc levels in HIV-infected adults in Cape Town, South Africa
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
VisserME_Plasma_vitamin_2003.pdf
Size:
137.83 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles