Thermal and structural characterization of two polymorphs of the bronchodilator tulobuterol
| dc.contributor.author | Caira, M R | |
| dc.contributor.author | Bourne, S A | |
| dc.contributor.author | Oliver, C L | |
| dc.date.accessioned | 2016-08-04T13:04:06Z | |
| dc.date.available | 2016-08-04T13:04:06Z | |
| dc.date.issued | 2004 | |
| dc.date.updated | 2016-08-01T11:36:03Z | |
| dc.description.abstract | Two polymorphs of the bronchodilator tulobuterol (2-chloro-α-[[(1,1-dimethylethyl)-amino] -methyl]benzenemethanol) with melting points differing by ∼10 K were isolated and characterized by thermal analysis (HSM, TG, DSC), as well as powder and single crystal X-ray diffraction. Analysis of melting data for Forms 1 and 2 revealed a monotropic relationship, with ∆G0, the Gibbs free energy difference at the melting temperature of the lower melting form, less than 1 kJ mol–1. This small difference is reconciled with known structural features in the crystals of the two forms. The hydrogen bonding capacity of the tulobuterol molecule is fully utilised in both polymorphs in forming a common trimeric unit via three strong O–H···N interactions. Consequently only weak intermolecular forces characterize the packing of the trimers in the monoclinic polymorph (Form 1, P21/n, Z =12) and the triclinic polymorph (Form 2, P(–1), Z =6). | en_ZA |
| dc.identifier | http://dx.doi.org/10.1023/B:JTAN.0000038997.18925.b3 | |
| dc.identifier.apacitation | Caira, M. R., Bourne, S. A., & Oliver, C. L. (2004). Thermal and structural characterization of two polymorphs of the bronchodilator tulobuterol. <i>Journal of Thermal Analysis and Calorimetry</i>, http://hdl.handle.net/11427/21118 | en_ZA |
| dc.identifier.chicagocitation | Caira, M R, S A Bourne, and C L Oliver "Thermal and structural characterization of two polymorphs of the bronchodilator tulobuterol." <i>Journal of Thermal Analysis and Calorimetry</i> (2004) http://hdl.handle.net/11427/21118 | en_ZA |
| dc.identifier.citation | Caira, M. R., Bourne, S. A., & Oliver, C. L. (2004). Thermal and structural characterization of two polymorphs of the bronchodilator tulobuterol. Journal of thermal analysis and calorimetry, 77(2), 597-606. | en_ZA |
| dc.identifier.issn | 1388-6150 | en_ZA |
| dc.identifier.ris | TY - Journal Article AU - Caira, M R AU - Bourne, S A AU - Oliver, C L AB - Two polymorphs of the bronchodilator tulobuterol (2-chloro-α-[[(1,1-dimethylethyl)-amino] -methyl]benzenemethanol) with melting points differing by ∼10 K were isolated and characterized by thermal analysis (HSM, TG, DSC), as well as powder and single crystal X-ray diffraction. Analysis of melting data for Forms 1 and 2 revealed a monotropic relationship, with ∆G0, the Gibbs free energy difference at the melting temperature of the lower melting form, less than 1 kJ mol–1. This small difference is reconciled with known structural features in the crystals of the two forms. The hydrogen bonding capacity of the tulobuterol molecule is fully utilised in both polymorphs in forming a common trimeric unit via three strong O–H···N interactions. Consequently only weak intermolecular forces characterize the packing of the trimers in the monoclinic polymorph (Form 1, P21/n, Z =12) and the triclinic polymorph (Form 2, P(–1), Z =6). DA - 2004 DB - OpenUCT DP - University of Cape Town J1 - Journal of Thermal Analysis and Calorimetry LK - https://open.uct.ac.za PB - University of Cape Town PY - 2004 SM - 1388-6150 T1 - Thermal and structural characterization of two polymorphs of the bronchodilator tulobuterol TI - Thermal and structural characterization of two polymorphs of the bronchodilator tulobuterol UR - http://hdl.handle.net/11427/21118 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/21118 | |
| dc.identifier.vancouvercitation | Caira MR, Bourne SA, Oliver CL. Thermal and structural characterization of two polymorphs of the bronchodilator tulobuterol. Journal of Thermal Analysis and Calorimetry. 2004; http://hdl.handle.net/11427/21118. | en_ZA |
| dc.language | eng | en_ZA |
| dc.publisher | Springer Verlag | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.source | Journal of Thermal Analysis and Calorimetry | en_ZA |
| dc.source.uri | http://www.springer.com/chemistry/physical+chemistry/journal/10973 | |
| dc.subject.other | β-adrenergic agonist | |
| dc.subject.other | DSC | |
| dc.subject.other | HSM | |
| dc.subject.other | Monotropy | |
| dc.subject.other | Polymorphism | |
| dc.subject.other | TG | |
| dc.subject.other | X-ray analysis | |
| dc.title | Thermal and structural characterization of two polymorphs of the bronchodilator tulobuterol | en_ZA |
| dc.type | Journal Article | en_ZA |
| uct.type.filetype | Text | |
| uct.type.filetype | Image | |
| uct.type.publication | Research | en_ZA |
| uct.type.resource | Article | en_ZA |