Flow velocity measurement in haemodialysis access using 4D MRI

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dc.contributor.advisorKahn, Delawiren_ZA
dc.contributor.advisorFranz, Thomasen_ZA
dc.contributor.authorDowns, Jenniferen_ZA
dc.date.accessioned2017-01-18T13:11:31Z
dc.date.available2017-01-18T13:11:31Z
dc.date.issued2016en_ZA
dc.description.abstractTreatment of renal failure while awaiting transplant requires vascular access, which comes with both complications and failure rates. In order to improve this, information about the AVF or AVG itself, as well as the haemodynamics is required. This data will then be used for computer modelling techniques and computational flow dynamics. Previously, the required imaging was provided by contrasted MRI, contraindicated in renal failure. Haemodynamic data was prvided by, amongst other things, duplex Doppler. New MRI software that provides imaging data as well as haemodynamic information without using contrast could be used to provide new high-quality data for modelling. Methods: This was a prospective pilot study. Six control cases (with no history of vascular illness or surgery of any kind to the right upper arm), as well as three grafts and five fistulae underwent phase contrast MR angiography of the right upper arm with a Siemens Magnetom Symphony 1.5T MRI Scanner. Images were then processed using Supertool in Matlab, and flow velocities at predetermined points on the brachial artery and cephalic vein, graft and fistula were calculated. Results: Velocities ranged from 5.8 cm/sec in a volunteer's brachial artery to 85.5 cm/sec in an arteriovenous fistula patient's brachial artery. Flow volumes in the cephalic vein or access varied from 6.9 ml/min. in a volunteer and up to 4398.1 ml/min. in an arteriovenous fistula. Graphical representations show marked haemodynamic changes throughout the imaged vessels. Conclusion: This technique provides good imaging and quantitative data about small vessel haemodynamics.en_ZA
dc.identifier.apacitationDowns, J. (2016). <i>Flow velocity measurement in haemodialysis access using 4D MRI</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Surgery. Retrieved from http://hdl.handle.net/11427/22797en_ZA
dc.identifier.chicagocitationDowns, Jennifer. <i>"Flow velocity measurement in haemodialysis access using 4D MRI."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Surgery, 2016. http://hdl.handle.net/11427/22797en_ZA
dc.identifier.citationDowns, J. 2016. Flow velocity measurement in haemodialysis access using 4D MRI. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Downs, Jennifer AB - Treatment of renal failure while awaiting transplant requires vascular access, which comes with both complications and failure rates. In order to improve this, information about the AVF or AVG itself, as well as the haemodynamics is required. This data will then be used for computer modelling techniques and computational flow dynamics. Previously, the required imaging was provided by contrasted MRI, contraindicated in renal failure. Haemodynamic data was prvided by, amongst other things, duplex Doppler. New MRI software that provides imaging data as well as haemodynamic information without using contrast could be used to provide new high-quality data for modelling. Methods: This was a prospective pilot study. Six control cases (with no history of vascular illness or surgery of any kind to the right upper arm), as well as three grafts and five fistulae underwent phase contrast MR angiography of the right upper arm with a Siemens Magnetom Symphony 1.5T MRI Scanner. Images were then processed using Supertool in Matlab, and flow velocities at predetermined points on the brachial artery and cephalic vein, graft and fistula were calculated. Results: Velocities ranged from 5.8 cm/sec in a volunteer's brachial artery to 85.5 cm/sec in an arteriovenous fistula patient's brachial artery. Flow volumes in the cephalic vein or access varied from 6.9 ml/min. in a volunteer and up to 4398.1 ml/min. in an arteriovenous fistula. Graphical representations show marked haemodynamic changes throughout the imaged vessels. Conclusion: This technique provides good imaging and quantitative data about small vessel haemodynamics. DA - 2016 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Flow velocity measurement in haemodialysis access using 4D MRI TI - Flow velocity measurement in haemodialysis access using 4D MRI UR - http://hdl.handle.net/11427/22797 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/22797
dc.identifier.vancouvercitationDowns J. Flow velocity measurement in haemodialysis access using 4D MRI. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Surgery, 2016 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/22797en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Surgeryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherSurgeryen_ZA
dc.titleFlow velocity measurement in haemodialysis access using 4D MRIen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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