Weight-for-age distributions among children with HIV on antiretroviral therapy in the International epidemiology Databases to Evaluate AIDS (IeDEA) multiregional consortium

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dc.contributor.authorJesson, Julie
dc.contributor.authorDesmonde, Sophie
dc.contributor.authorYiannoutsos, Constantin T
dc.contributor.authorPatten, Gabriela
dc.contributor.authorMalateste, Karen
dc.contributor.authorDuda, Stephany N
dc.contributor.authorKumarasamy, Nagalingeswaran
dc.contributor.authorYotebieng, Marcel
dc.contributor.authorDavies, Mary-Ann
dc.contributor.authorMusick, Beverly
dc.contributor.authorLeroy, Valeriane
dc.contributor.authorCiaranello, Andrea
dc.date.accessioned2020-06-11T16:37:47Z
dc.date.available2020-06-11T16:37:47Z
dc.date.issued2020-05-24
dc.date.updated2020-05-31T03:15:45Z
dc.description.abstractObjective Pediatric antiretroviral therapy (ART) for children with HIV (CHIV) must be dosed appropriately for children’s changing weights as they grow. To inform accurate estimates of ART formulations and doses needed, we described weight-for-age distributions among CHIV on ART in the IeDEA global pediatric collaboration between 2004 and 2016, using data from six regions (East, West, Central, and Southern Africa, Asia–Pacific, and Central/South America and the Caribbean). Results Overall, 59,862 children contributed to the analysis. Age and weight data were available from 530,080 clinical encounters for girls and 537,894 for boys. For each one-year age stratum from 0 to 15 years, we calculated the proportion of children in each of the weight bands designated by the World Health Organization as relevant to pediatric ART formulations: 0 to  < 3 kg, 3 to  < 6 kg, 6 to  < 10 kg, 10 to  < 14 kg, 14 to  < 20 kg, 20 to  < 25 kg, 25 to  < 30 kg, 30 to  < 35 kg, 35 to  < 40 kg, 40 to  < 45 kg, 45 to  < 50 kg, 50 to  < 55 kg, 55 to  < 60 kg, and ≥ 60 kg. Data are reported for the entire cohort, as well as stratified by sex and IeDEA region, calendar year of ART use, and duration on ART at time of assessment (< 12 or ≥ 12 months), provided in data tables. These data are critical to improve the accuracy of forecasting and procurement of pediatric ART formulations as the pediatric HIV epidemic and pediatric HIV treatment strategies evolve.en_US
dc.identifier.apacitationJesson, J., Desmonde, S., Yiannoutsos, C. T., Patten, G., Malateste, K., Duda, S. N., ... Ciaranello, A. (2020). Weight-for-age distributions among children with HIV on antiretroviral therapy in the International epidemiology Databases to Evaluate AIDS (IeDEA) multiregional consortium. <i>BMC Res Notes</i>, 13(1), 249. http://hdl.handle.net/11427/32067en_ZA
dc.identifier.chicagocitationJesson, Julie, Sophie Desmonde, Constantin T Yiannoutsos, Gabriela Patten, Karen Malateste, Stephany N Duda, Nagalingeswaran Kumarasamy, et al "Weight-for-age distributions among children with HIV on antiretroviral therapy in the International epidemiology Databases to Evaluate AIDS (IeDEA) multiregional consortium." <i>BMC Res Notes</i> 13, 1. (2020): 249. http://hdl.handle.net/11427/32067en_ZA
dc.identifier.citationJesson, J., Desmonde, S., Yiannoutsos, C.T., Patten, G., Malateste, K., Duda, S.N., Kumarasamy, N. & Yotebieng, M. et al. 2020. Weight-for-age distributions among children with HIV on antiretroviral therapy in the International epidemiology Databases to Evaluate AIDS (IeDEA) multiregional consortium. <i>BMC Res Notes.</i> 13(1):249. http://hdl.handle.net/11427/32067en_ZA
dc.identifier.ris TY - Journal Article AU - Jesson, Julie AU - Desmonde, Sophie AU - Yiannoutsos, Constantin T AU - Patten, Gabriela AU - Malateste, Karen AU - Duda, Stephany N AU - Kumarasamy, Nagalingeswaran AU - Yotebieng, Marcel AU - Davies, Mary-Ann AU - Musick, Beverly AU - Leroy, Valeriane AU - Ciaranello, Andrea AB - Objective Pediatric antiretroviral therapy (ART) for children with HIV (CHIV) must be dosed appropriately for children’s changing weights as they grow. To inform accurate estimates of ART formulations and doses needed, we described weight-for-age distributions among CHIV on ART in the IeDEA global pediatric collaboration between 2004 and 2016, using data from six regions (East, West, Central, and Southern Africa, Asia–Pacific, and Central/South America and the Caribbean). Results Overall, 59,862 children contributed to the analysis. Age and weight data were available from 530,080 clinical encounters for girls and 537,894 for boys. For each one-year age stratum from 0 to 15 years, we calculated the proportion of children in each of the weight bands designated by the World Health Organization as relevant to pediatric ART formulations: 0 to  < 3 kg, 3 to  < 6 kg, 6 to  < 10 kg, 10 to  < 14 kg, 14 to  < 20 kg, 20 to  < 25 kg, 25 to  < 30 kg, 30 to  < 35 kg, 35 to  < 40 kg, 40 to  < 45 kg, 45 to  < 50 kg, 50 to  < 55 kg, 55 to  < 60 kg, and ≥ 60 kg. Data are reported for the entire cohort, as well as stratified by sex and IeDEA region, calendar year of ART use, and duration on ART at time of assessment (< 12 or ≥ 12 months), provided in data tables. These data are critical to improve the accuracy of forecasting and procurement of pediatric ART formulations as the pediatric HIV epidemic and pediatric HIV treatment strategies evolve. DA - 2020-05-24 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - BMC Res Notes KW - Pediatric HIV KW - Pediatric antiretroviral therapy KW - Antiretroviral formulation KW - Weight-for-age LK - https://open.uct.ac.za PY - 2020 T1 - Weight-for-age distributions among children with HIV on antiretroviral therapy in the International epidemiology Databases to Evaluate AIDS (IeDEA) multiregional consortium TI - Weight-for-age distributions among children with HIV on antiretroviral therapy in the International epidemiology Databases to Evaluate AIDS (IeDEA) multiregional consortium UR - http://hdl.handle.net/11427/32067 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s13104-020-05081-7
dc.identifier.urihttp://hdl.handle.net/11427/32067
dc.identifier.vancouvercitationJesson J, Desmonde S, Yiannoutsos CT, Patten G, Malateste K, Duda SN, et al. Weight-for-age distributions among children with HIV on antiretroviral therapy in the International epidemiology Databases to Evaluate AIDS (IeDEA) multiregional consortium. BMC Res Notes. 2020;13(1):249. http://hdl.handle.net/11427/32067.en_ZA
dc.language.isoenen_US
dc.language.rfc3066en
dc.publisher.departmentDepartment of Public Health and Family Medicineen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceBMC Res Notesen_US
dc.source.journalissue1en_US
dc.source.journalvolume13en_US
dc.source.pagination249en_US
dc.source.urihttps://bmcresnotes.biomedcentral.com/
dc.subjectPediatric HIVen_US
dc.subjectPediatric antiretroviral therapyen_US
dc.subjectAntiretroviral formulationen_US
dc.subjectWeight-for-ageen_US
dc.titleWeight-for-age distributions among children with HIV on antiretroviral therapy in the International epidemiology Databases to Evaluate AIDS (IeDEA) multiregional consortiumen_US
dc.typeJournal Articleen_US
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