Splenectomy for immune thrombocytopenia : our 11-year experience

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dc.contributor.advisorNovitzky, Nicolasen_ZA
dc.contributor.authorAntel, Katherineen_ZA
dc.date.accessioned2015-09-30T13:43:59Z
dc.date.available2015-09-30T13:43:59Z
dc.date.issued2015en_ZA
dc.description.abstractSplenectomy has been practiced for the treatment of ITP for the past few decades. Currently it is utilised when a patient is either dependent or resistant to steroid treatment and the platelet count remains less than 30×109/L. Recently new agents have been added to the armamentarium used to treat ITP, including immune-suppressants such as rituximab and the new thrombopoetin-receptor agonists. This has brought into question the role of surgery for the treatment of ITP, and the need to compare the response and complication rates of splenectomy to these newer agents. Historic studies done on splenectomy for the treatment of ITP have been performed in the setting of low HIV prevalence. There is a relative paucity of data on the response rate in HIV-associated thrombocytopenia to splenectomy and the durability of response to splenectomy is unclear in this patient population. We retrospectively analysed 73 consecutive patients who underwent splenectomy for ITP from 2001 to 2011. The primary objective was to determine the rate of complete response, this was defined as a platelet count greater than 100×109/L at one year post splenectomy. Results were compared between HIV positive and HIV negative patients. The secondary objectives were: to evaluate the intra-operative and post†operative complications and mortality in the HIV positive and HIV negative groups, and to investigate for associations between co-morbidities, pre-operative treatment and response to splenectomy.en_ZA
dc.identifier.apacitationAntel, K. (2015). <i>Splenectomy for immune thrombocytopenia : our 11-year experience</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/14134en_ZA
dc.identifier.chicagocitationAntel, Katherine. <i>"Splenectomy for immune thrombocytopenia : our 11-year experience."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2015. http://hdl.handle.net/11427/14134en_ZA
dc.identifier.citationAntel, K. 2015. Splenectomy for immune thrombocytopenia : our 11-year experience. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Antel, Katherine AB - Splenectomy has been practiced for the treatment of ITP for the past few decades. Currently it is utilised when a patient is either dependent or resistant to steroid treatment and the platelet count remains less than 30×109/L. Recently new agents have been added to the armamentarium used to treat ITP, including immune-suppressants such as rituximab and the new thrombopoetin-receptor agonists. This has brought into question the role of surgery for the treatment of ITP, and the need to compare the response and complication rates of splenectomy to these newer agents. Historic studies done on splenectomy for the treatment of ITP have been performed in the setting of low HIV prevalence. There is a relative paucity of data on the response rate in HIV-associated thrombocytopenia to splenectomy and the durability of response to splenectomy is unclear in this patient population. We retrospectively analysed 73 consecutive patients who underwent splenectomy for ITP from 2001 to 2011. The primary objective was to determine the rate of complete response, this was defined as a platelet count greater than 100×109/L at one year post splenectomy. Results were compared between HIV positive and HIV negative patients. The secondary objectives were: to evaluate the intra-operative and post†operative complications and mortality in the HIV positive and HIV negative groups, and to investigate for associations between co-morbidities, pre-operative treatment and response to splenectomy. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Splenectomy for immune thrombocytopenia : our 11-year experience TI - Splenectomy for immune thrombocytopenia : our 11-year experience UR - http://hdl.handle.net/11427/14134 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14134
dc.identifier.vancouvercitationAntel K. Splenectomy for immune thrombocytopenia : our 11-year experience. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/14134en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherHaematologyen_ZA
dc.titleSplenectomy for immune thrombocytopenia : our 11-year experienceen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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