Evaluation of the P13K pathway and downstream effect in Her-2 positive and negative breast carcinomas

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dc.contributor.advisorGovender, Dhirenen_ZA
dc.contributor.authorRademan, Aninaen_ZA
dc.date.accessioned2015-09-15T10:22:33Z
dc.date.available2015-09-15T10:22:33Z
dc.date.issued2014en_ZA
dc.description.abstractBreast cancer management continues to be a challenge due to the heterogeneity of the disease and the fact that individuals with the same stage and pathological diagnosis may respond differently to treatment as a result of differences in gene expression. Several components of the Her-2/PI3K/Akt pathway were evaluated for their relevance as potential prognostic markers or indicators for treatment. A secondary objective was to evaluate the CISH technique for its suitability for analysis of Her-2 gene amplification on archived, Papanicolaou-stained fine needle aspiration (FNA) samples. Tissue blocks from a retrospective series of 93 primary breast carcinoma cases were selected, based on their Her-2 status. Twenty six of these cases received trastuzumab treatment while 67 did not. Expression of Her-2, ER, PI3K, PTEN, p-Akt, BCL2, NFκB, MDM2 and p53 were analysed and compared with various clinicopathological features. The CISH technique was evaluated for its suitability for analysis of Her-2 gene amplification on archived, Papanicolaou-stained FNA samples.en_ZA
dc.identifier.apacitationRademan, A. (2014). <i>Evaluation of the P13K pathway and downstream effect in Her-2 positive and negative breast carcinomas</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Anatomical Pathology. Retrieved from http://hdl.handle.net/11427/13965en_ZA
dc.identifier.chicagocitationRademan, Anina. <i>"Evaluation of the P13K pathway and downstream effect in Her-2 positive and negative breast carcinomas."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Anatomical Pathology, 2014. http://hdl.handle.net/11427/13965en_ZA
dc.identifier.citationRademan, A. 2014. Evaluation of the P13K pathway and downstream effect in Her-2 positive and negative breast carcinomas. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Rademan, Anina AB - Breast cancer management continues to be a challenge due to the heterogeneity of the disease and the fact that individuals with the same stage and pathological diagnosis may respond differently to treatment as a result of differences in gene expression. Several components of the Her-2/PI3K/Akt pathway were evaluated for their relevance as potential prognostic markers or indicators for treatment. A secondary objective was to evaluate the CISH technique for its suitability for analysis of Her-2 gene amplification on archived, Papanicolaou-stained fine needle aspiration (FNA) samples. Tissue blocks from a retrospective series of 93 primary breast carcinoma cases were selected, based on their Her-2 status. Twenty six of these cases received trastuzumab treatment while 67 did not. Expression of Her-2, ER, PI3K, PTEN, p-Akt, BCL2, NFκB, MDM2 and p53 were analysed and compared with various clinicopathological features. The CISH technique was evaluated for its suitability for analysis of Her-2 gene amplification on archived, Papanicolaou-stained FNA samples. DA - 2014 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Evaluation of the P13K pathway and downstream effect in Her-2 positive and negative breast carcinomas TI - Evaluation of the P13K pathway and downstream effect in Her-2 positive and negative breast carcinomas UR - http://hdl.handle.net/11427/13965 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/13965
dc.identifier.vancouvercitationRademan A. Evaluation of the P13K pathway and downstream effect in Her-2 positive and negative breast carcinomas. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Anatomical Pathology, 2014 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/13965en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Anatomical Pathologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherAnatomical Pathologyen_ZA
dc.titleEvaluation of the P13K pathway and downstream effect in Her-2 positive and negative breast carcinomasen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMSc (Med)en_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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