Neuropsychiatric symptoms in thymoma-associated and non-thymoma myasthenia gravis

Master Thesis

2012

Permanent link to this Item
http://hdl.handle.net/11427/11996
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thesis_hsf_2012_freeman_cp.pdf (3.44 MB)
Authors
Freeman, Carla Patricia
Supervisors
Heckmann, Jeannine
Lewis, Ian Storm
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University of Cape Town

Department
Department of Psychiatry and Mental Health
Faculty
Faculty of Health Sciences
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Abstract
Myasthenia gravis (MG) is an acetylcholine receptor antibody- mediated disease targeting the neuromuscular junction resulting in fatigable muscle weakness. A number of reports have suggested a high prevalence of psychiatric symptoms amongst MG patients. Approximately 10% of MG subjects are found to have an associated thymoma and despite thymomectomy, the MG persists. The presence of thymoma may lead to other antibody-mediated neuropsychiatric manifestations including limbic encephalitis. We hypothesized that the prevalence of neuropsychiatric symptoms may be higher in MG subjects with thymoma-associated MG when compared with those who have non-thymoma MG. This study aims to compare the prevalence of neuropsychiatric symptoms in a South African population of non-thymoma MG and thymoma-associated MG.
Description

Includes abstract.


Includes bibliographical references.

Keywords
Psychiatry

Reference:

Freeman, C. 2012. Neuropsychiatric symptoms in thymoma-associated and non-thymoma myasthenia gravis. University of Cape Town.

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