Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis

 

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dc.contributor.advisor Jackson, Graham Ellis en_ZA
dc.contributor.author Mhlambiso, Zizile en_ZA
dc.date.accessioned 2014-11-05T17:41:58Z
dc.date.available 2014-11-05T17:41:58Z
dc.date.issued 2009 en_ZA
dc.identifier.citation Mhlambiso, Z. 2009. Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/9280
dc.description Includes bibliographical references. en_ZA
dc.description.abstract It has been shown that copper complexes are able to alleviate inflammation associated with Rheumatoid Arthritis (RA). Serum copper levels are elevated in RA and it has been postulated that endogenous copper might have a protective function in chronic inflammatory conditions. In designing Cu(I1) anti-inflammatory drugs, one needs to know the stability constants of the ligand together with Cu(I1) and the competitive metal ions, Zn(I1) and Ca(I1) in blood plasma. For this purpose glass electrode potentiometry, infrared (lR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, UV/Visible spectroscopy as well as blood plasma modelling were used to explore the coordination chemistry of a newly designed ligand, PCUL (Bis-(3- aminoethy-2-aminomethylpyridine )-oxahexacyclo-dodecane). PCUL protonation and formation constants with Cu(I1) and Zn(I1) were investigated by potentiometric analysis at 2SoC and 0.ISmol/dm3 Na + (CI) The potentiometric analysis showed that CU(I1) formed far more stable complexes at physiological pH with PCUL than the in vivo competitor Zn(I1). In this study the IR spectroscopic analysis was used to determine the Cu(I1)-PCUL complexation sequence. The IR spectra show that the central amines are coordinated to the metal ion first. The small frequency shift between pH 4.02 to 6.91 proves that the pyridyl nitrogen atoms are also coordinated to CU(I1). en_ZA
dc.language.iso eng en_ZA
dc.subject.other Chemistry en_ZA
dc.title Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Chemistry en_ZA
dc.type.qualificationlevel Masters en_ZA
dc.type.qualificationname MSc en_ZA
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