Allocentric spatial memory following anterior temporal lobectomy: A comparison between active and sedentary epileptic adults

 

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dc.contributor.advisor Thomas, Kevin en_ZA
dc.contributor.author Cotton, Sarah en_ZA
dc.date.accessioned 2014-10-08T09:44:06Z
dc.date.available 2014-10-08T09:44:06Z
dc.date.issued 2009 en_ZA
dc.identifier.citation Cotton, S. 2009. Allocentric spatial memory following anterior temporal lobectomy: A comparison between active and sedentary epileptic adults. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/8268
dc.description.abstract The association between neural activity of the left hemisphere hippocampal region and verbal memory has been well established. Similarly, neuropsychological outcomes following left anterior temporal lobectomy (ATL) have been well documented, with deficits in the ability to learn new verbally encoded material consistently displayed. However, the association between non-verbal memory and functioning of the right hemisphere hippocampal region and, consequently, neuropsychological outcomes following right ATL, remains an area of debate. Moreover, relatively new evidence suggests that physical activity could improve overall hippocampal function (McCloskey, 2003). Therefore, the aim of the present study was to investigate spatial cognition in patients with intractable epilepsy and also to establish whether physical activity levels of these patients, i.e. active versus sedentary, had an effect on neuropsychological functioning. Spatial and verbal cognition were assessed in three groups: a pre-surgical (awaiting ATL) group, a post-surgical (following ATL) group and a healthy control group. Physical activity levels of all participants were established and left-sided damage and right-sided damage patient groups were divided into those with moderate-to-high activity levels and those with low activity levels. Results showed that on tests of spatial cognition, patients with right-sided damage tended to show more deficits than patients with left-sided damage when assessed using experimental tasks. However, no group differences were found when using standard clinical tests for assessment. On tests of verbal memory, patients with left-sided damage displayed more deficits than patients with right-sided damage. Patients with moderate-high activity levels performed better than patients with low activity levels on tests of spatial cognition, but both groups performed similarly on tests of verbal memory. The data therefore largely confirm the hypotheses. This is the first demonstration, within a single study, of spatial memory deficits using a virtual environment spatial navigation task in epileptic adults; and of an association between activity levels and improved spatial cognition on the CG Arena task in epileptic adults. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Psychology en_ZA
dc.title Allocentric spatial memory following anterior temporal lobectomy: A comparison between active and sedentary epileptic adults en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Humanities en_ZA
dc.publisher.department Department of Psychology en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MA en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Cotton, S. (2009). <i>Allocentric spatial memory following anterior temporal lobectomy: A comparison between active and sedentary epileptic adults</i>. (Thesis). University of Cape Town ,Faculty of Humanities ,Department of Psychology. Retrieved from http://hdl.handle.net/11427/8268 en_ZA
dc.identifier.chicagocitation Cotton, Sarah. <i>"Allocentric spatial memory following anterior temporal lobectomy: A comparison between active and sedentary epileptic adults."</i> Thesis., University of Cape Town ,Faculty of Humanities ,Department of Psychology, 2009. http://hdl.handle.net/11427/8268 en_ZA
dc.identifier.vancouvercitation Cotton S. Allocentric spatial memory following anterior temporal lobectomy: A comparison between active and sedentary epileptic adults. [Thesis]. University of Cape Town ,Faculty of Humanities ,Department of Psychology, 2009 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/8268 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Cotton, Sarah AB - The association between neural activity of the left hemisphere hippocampal region and verbal memory has been well established. Similarly, neuropsychological outcomes following left anterior temporal lobectomy (ATL) have been well documented, with deficits in the ability to learn new verbally encoded material consistently displayed. However, the association between non-verbal memory and functioning of the right hemisphere hippocampal region and, consequently, neuropsychological outcomes following right ATL, remains an area of debate. Moreover, relatively new evidence suggests that physical activity could improve overall hippocampal function (McCloskey, 2003). Therefore, the aim of the present study was to investigate spatial cognition in patients with intractable epilepsy and also to establish whether physical activity levels of these patients, i.e. active versus sedentary, had an effect on neuropsychological functioning. Spatial and verbal cognition were assessed in three groups: a pre-surgical (awaiting ATL) group, a post-surgical (following ATL) group and a healthy control group. Physical activity levels of all participants were established and left-sided damage and right-sided damage patient groups were divided into those with moderate-to-high activity levels and those with low activity levels. Results showed that on tests of spatial cognition, patients with right-sided damage tended to show more deficits than patients with left-sided damage when assessed using experimental tasks. However, no group differences were found when using standard clinical tests for assessment. On tests of verbal memory, patients with left-sided damage displayed more deficits than patients with right-sided damage. Patients with moderate-high activity levels performed better than patients with low activity levels on tests of spatial cognition, but both groups performed similarly on tests of verbal memory. The data therefore largely confirm the hypotheses. This is the first demonstration, within a single study, of spatial memory deficits using a virtual environment spatial navigation task in epileptic adults; and of an association between activity levels and improved spatial cognition on the CG Arena task in epileptic adults. DA - 2009 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Allocentric spatial memory following anterior temporal lobectomy: A comparison between active and sedentary epileptic adults TI - Allocentric spatial memory following anterior temporal lobectomy: A comparison between active and sedentary epileptic adults UR - http://hdl.handle.net/11427/8268 ER - en_ZA


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