Rationalising the effect of guanine-based Ricin inhibitors using computer simulations

 

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dc.contributor.advisor Naidoo, Kevin J en_ZA
dc.contributor.author Jayakody, Ranga S en_ZA
dc.date.accessioned 2014-08-13T14:26:36Z
dc.date.available 2014-08-13T14:26:36Z
dc.date.issued 2008 en_ZA
dc.identifier.citation Jayakody, R. 2008. Rationalising the effect of guanine-based Ricin inhibitors using computer simulations. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/6315
dc.description Includes abstract. en_ZA
dc.description Includes bibliographical references (leaves 99-101). en_ZA
dc.description.abstract for humans.This has lead to its use as a biological weapon and a therapeutic agent. the reaction mechanism of ricin is not known and so rational design is limited, resulting in no effective inhibitor being found for this enzyme. An important step towards understanding the reaction mechanism and the design of effective inhibitors is the complete understanding of the binding pocket and the mode/nature of binding ligands to the protein. In this thesis computational methods were used to rationalise the effect of selected ricin inhibitors. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Chemistry en_ZA
dc.title Rationalising the effect of guanine-based Ricin inhibitors using computer simulations en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Chemistry en_ZA
dc.type.qualificationlevel Masters en_ZA
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image


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