Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene

 

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dc.contributor.advisor Caira, Mino R en_ZA
dc.contributor.advisor Hunter, Roger en_ZA
dc.contributor.advisor Bourne, Susan en_ZA
dc.contributor.author Smith, Vincent Joseph en_ZA
dc.date.accessioned 2014-08-13T14:25:55Z
dc.date.available 2014-08-13T14:25:55Z
dc.date.issued 2004 en_ZA
dc.identifier.citation Smith, V. 2004. Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/6293
dc.description Includes bibliographical references. en_ZA
dc.description.abstract This study describes the preparation and physicochemical characterization of inclusion complexes formed between selected cyclodextrins (CDs) and ajoene, an antlthrombotlc found in garlic. The E and Z isomers of ajoene (4,5,9,-trithiadodeca-1,6,11-triene-9-oxide) were reacted with α, β, γ-CD heptakis(2,6-di-O-methyl )-β-CD (DIMEB) and heptakls(2, 3, 6-tri-O-methyl )-β-CD (TRIMEB) to yield inclusion compounds α-CD·(E)-ajoene (1), α-CD·(Z)ajoene (2), β-CD·(E)-ajoene (3), β-CD·(Z)-ajoene (4), y-CD·(E)-ajoene (5), y-CD·(Z)-ajoene (6), DIMEB·(E)-ajoene (7), DIMEB·(Z)-ajoene (6), TRIMEB·(E)-ajoene·05H20 (9) and TRIMEB·(Z)-ajoene (10). en_ZA
dc.language.iso eng en_ZA
dc.subject.other Chemistry en_ZA
dc.title Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Chemistry en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Smith, V. J. (2004). <i>Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/6293 en_ZA
dc.identifier.chicagocitation Smith, Vincent Joseph. <i>"Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2004. http://hdl.handle.net/11427/6293 en_ZA
dc.identifier.vancouvercitation Smith VJ. Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2004 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6293 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Smith, Vincent Joseph AB - This study describes the preparation and physicochemical characterization of inclusion complexes formed between selected cyclodextrins (CDs) and ajoene, an antlthrombotlc found in garlic. The E and Z isomers of ajoene (4,5,9,-trithiadodeca-1,6,11-triene-9-oxide) were reacted with α, β, γ-CD heptakis(2,6-di-O-methyl )-β-CD (DIMEB) and heptakls(2, 3, 6-tri-O-methyl )-β-CD (TRIMEB) to yield inclusion compounds α-CD·(E)-ajoene (1), α-CD·(Z)ajoene (2), β-CD·(E)-ajoene (3), β-CD·(Z)-ajoene (4), y-CD·(E)-ajoene (5), y-CD·(Z)-ajoene (6), DIMEB·(E)-ajoene (7), DIMEB·(Z)-ajoene (6), TRIMEB·(E)-ajoene·05H20 (9) and TRIMEB·(Z)-ajoene (10). DA - 2004 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2004 T1 - Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene TI - Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene UR - http://hdl.handle.net/11427/6293 ER - en_ZA


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