Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents

 

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dc.contributor.advisor Chibale, Kelly en_ZA
dc.contributor.author Watermeyer, Nicholas D en_ZA
dc.date.accessioned 2014-08-13T14:25:31Z
dc.date.available 2014-08-13T14:25:31Z
dc.date.issued 2008 en_ZA
dc.identifier.citation Watermeyer, N. 2008. Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/6283
dc.description Includes bibliographical references. en_ZA
dc.description Includes bibliographical references. en_ZA
dc.description.abstract Chloroquine(CO)-derived 4-aminoquinolines have proven to be the most efficacious antimalarial drugs for both the treatment and prophylaxis of malaria. However, with the advent of drug resistance, their ability to treat the disease has been significantly hindered. Future research into the synthesis of new 4-aminoquinoline derivatives is warranted, since it has been found that the resistance is based on the identity of the side chain and not on the aminoquinoline ring, the functionality by which these compounds derive their activity. Consequently, the synthesis of CO derivatives with a modified side chain attached to a substituted quinoline ring is a reasonable approach in the search of novel antimalarial compounds that are active against drug-resistant parasite strains. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Chemistry en_ZA
dc.title Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Chemistry en_ZA
dc.type.qualificationlevel Masters en_ZA
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image


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